Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity

This study is looking for adults who smoke daily and have high anxiety sensitivity (a fear of bodily sensations) to test a new approach to quitting. It combines standard smoking cessation methods like counseling from the Texas Tobacco Quitline and nicotine patches with a 15-week aerobic exercise program at the YMCA. The goal is to see if this personalized approach helps people with high anxiety sensitivity successfully quit smoking. To join, you need to be at least 18, smoke at least 5 cigarettes a day for over a year, be motivated to quit, and have medical clearance for exercise. The study aims to enroll 360 participants, but its current status is unclear.

Study design
This interventional study plans to enroll 360 participants. It compares a high-intensity exercise intervention with a low-intensity exercise intervention, in addition to counseling and nicotine patches.
What's involved
You would participate in a 15-week exercise intervention at a YMCA, receive up to 5 interactions from the Texas Tobacco Quitline, and use nicotine patches for 8 weeks starting at week 6.
Compensation
Not stated in the trial record.
Follow-up
Your smoking status will be checked 6 months after your target quit day (at protocol week 30).

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NCT06053567

Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity.

Recruiting
PHASE3Ages 18+InterventionalTreatment
Jasper A. Smits
~360 participants
Updated 2026-05-15 on ClinicalTrials.gov
What's tested:Aerobic ExerciseCounselingNicotine patch

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
7-day point prevalence abstinence (PPA) at 6-month follow-up
Measured over Protocol week 30, which is 24 weeks (6 months) after the quit attempt (set at week 6)
Nicotine Dependence
1 sites across 1 states
Texas1
  • Jasper Smits, PhD · PRINCIPAL_INVESTIGATOR · University of Texas at Austin

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Eligibility criteria

Inclusion

Adult (age ≥ 18);
High Anxiety Sensitivity (≥5 on the Short Scale Anxiety Sensitivity Index \[SSASI\]);
Daily smoker, ≥5 cigarettes (including e-cigarettes, little cigars/cigarillos) for ≥1 year;
Motivated to quit smoking as evidenced by a score of ≥5 on a 0-10 Likert scale;
Body mass index \< 40;
Medical clearance to participate.
Located near a participating YMCA site (within 50 miles)

Exclusion

Regular exercise defined as engaging in vigorous-intensity exercise for at least 75 minutes per week for the last 3 months
Receiving current intervention for smoking cessation.
Outstanding debt to the YMCA
Listed as a sex offender on the National Sex Offender Registry
  • 7-day point prevalence abstinence (PPA) at 6-month follow-upProtocol week 30, which is 24 weeks (6 months) after the quit attempt (set at week 6)

    Self-report of no smoking (not even a puff) during the previous 7 days, verified by expired carbon monoxide (CO; ≤5ppm), saliva cotinine (\<30 ng/mL), or significant other, and not invalidated by any of these verification measures. Failure to provide any of these 3 verification measures will result in PPA being considered missing.