NCT06055712
Antibiotic Prophylaxis in Pediatric Open Fractures
Enrolling by Invitation
PHASE4Ages 0–17InterventionalPreventionSt. Louis UniversityInvestigator-initiated
~800 participants
Updated 2025-10-20 on ClinicalTrials.gov
What's tested:CefazolinCephalexin
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants with an infection at the fracture site.
Measured over Up to 3 months following injury.
Conditions
Where it's being run
1 sites across 1 statesMissouri1
Study leadership
- Sivashanmugam Raju, MD · PRINCIPAL_INVESTIGATOR · St. Louis University
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Pediatric patients ages 0-17 years old
Skeletally immature patients, as confirmed by xray imaging evaluated by an orthopaedic surgeon
Patient as sustained a grade 1 or 2 open fracture within 24 hours of presentation
Physician plans to manage the fracture non-operatively
Exclusion
Patients 18 years or older
Skeletally mature patients, as as confirmed by xray imaging evaluated by an orthopaedic surgeon
Patients with grade 3 open fractures
Gross contamination of the fracture
Fracture requires surgery
Immunocompromised patients
Allergies to cephalosporins
Severe penicillin allergy
non-English speaking patients \&/or guardian
What this trial measures
- Number of participants with an infection at the fracture site.Up to 3 months following injury.
Participants will be monitored for infection at follow-up appointments and/or through follow-up phone contact.