Understanding Drug Excretion in Breast Milk
This study is looking at how the drug cimetidine (used to treat heartburn and ulcers) gets into breast milk. Researchers want to understand how certain proteins (OCT1 and BCRP) in the breast gland affect this process. You might be able to join if you are a healthy woman between 18 and 50 years old who has recently given birth and is breastfeeding. The study will measure how much cimetidine is in your breast milk at different times after you take it. This will help us understand how drugs are passed to infants through breast milk. The study plans to enroll 50 participants, but its current status is unclear.
- Study design
- This is an interventional study that is not randomized and does not specify a phase. It plans to enroll 50 participants.
- What's involved
- You will receive a single dose of cimetidine on three separate study days (3-5 weeks, 3-4 months, and 6-8 months postpartum). On each of these days, you will provide blood, urine, and breast milk samples over 12 hours.
- Compensation
- Not stated in the trial record.
- Follow-up
- You will be followed at 3-5 weeks, 3-4 months, and 6-8 months postpartum.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Drug Excretion in Breast Milk
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Mary Hebert, PharmD, FCCP · PRINCIPAL_INVESTIGATOR · University of Washington
Who to contact
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What this trial measures
- Mammary clearance of cimetidine3-5 weeks, 3-4 months and 6-8 months postpartum
Cimetidine excretion into breast milk at three postpartum stages
- Mammary epithelial cell expression of BCRP3-5 weeks, 3-4 months and 6-8 months postpartum
BCRP protein expression in MECs at three postpartum stages
- Mammary epithelial cell expression of OCT13-5 weeks, 3-4 months and 6-8 months postpartum
OCT1 protein expression in MECs at three postpartum stages