Helix Research Network: Understanding Genetic Predisposition to Disease
This study, called the Helix Research Network, aims to create a large collection of genetic and health information to help researchers better understand diseases. They will do this by performing exome sequencing (looking at all the protein-coding genes in your DNA) on samples from participants. The goal is to find genetic factors that influence disease risk, how diseases progress, and how people respond to treatments. This information could lead to better ways to diagnose and treat illnesses. You can join if you are 18 or older and can follow the study's instructions. The study is ongoing and plans to enroll a very large number of participants.
- Study design
- This is an observational study, meaning researchers will collect information without giving you a specific treatment. It plans to enroll 2,000,000 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Researchers plan to re-contact participants and aggregate data throughout the study, which is expected to last an average of 10 years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Helix Research Network
At a glance
Conditions
Where it's being run
14 sites across 11 statesStudy leadership
- William Lee, PhD · PRINCIPAL_INVESTIGATOR · Helix, Inc
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Establish a Research NetworkThrough study completion, average 10 years
Establish a research network to support the advancement of biomedical research, improve human health through genomics research, and accelerate integration of genomic and other omics data into clinical care.
- Aggregate dataThrough study completion, average 10 years
Aggregate molecular, genomic data, phenotypic and other health-related data in centralized and/or federated databases to be accessed by investigators for approved research purposes.
- Re-Contact participantsThrough study completion, average 10 years
Recontact participants for additional data collection, research participation opportunities, and return of results
- Genetic biomarker identificationThrough study completion, average 10 years
Identification and characterization of clinical, histological, molecular, and genetic biomarkers that are linked to disease, disease outcomes, or that might be used to improvise disease classification.
- Exploration of genetic determinants of diseaseThrough study completion, average 10 years
Exploration of the molecular and genetic underpinnings and determinants of disease, including disease risk, disease progression, treatment response, health economic outcomes, social or behavioral determinants of health, targets for therapeutic intervention, risk stratification, and other clinical indicators of interest.
- Collection and analysis of Patient Reported OutcomesThrough study completion, average 10 years
Collection and analysis of Patient Reported Outcomes (e.g. quality of life, physical function, symptom burden) associated with diseases that have a genetic or molecular etiology. Validation of disease-specific instruments to assess the impact of genetic screening.