Tranexamic Acid for Nasal Mohs Reconstruction
This study is looking at whether a medication called tranexamic acid (TXA) can help reduce swelling and bruising after nasal reconstruction surgery. This surgery often happens after Mohs surgery for skin cancer on the face. You would receive an injection of either tranexamic acid mixed with a local anesthetic (1% lidocaine with 1:100,000 epinephrine) or just the local anesthetic. Researchers want to see if tranexamic acid, which helps blood clot, can improve how your surgical site looks and feels. To join, you must be at least 18 years old and having a specific type of nasal reconstruction surgery (local flap) at Vanderbilt University Medical Center. The study will measure swelling and bruising one week after surgery, and bleeding during surgery. The current recruitment status is unclear.
- Study design
- This is a randomized controlled trial planning to enroll 100 participants. Participants will be randomly assigned to receive either the treatment or the control injection.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your surgical site swelling and bruising will be measured one week after surgery.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Tranexamic Acid in Nasal Mohs Reconstruction
At a glance
Conditions
NCT06057675
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Vanderbilt University Medical Center
Nashville, Tennesseeno site contact published
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Priyesh Patel, MD · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Surgical site swelling and bruising (surgeon)One week
Photos will be taken by a research team member at the first postoperative clinic visit and then analyzed and graded by a blinded reviewer for measures including surgical site bruising and swelling. Surgical site swelling and bruising will be graded on a 4 point scale, with 0 indicating no swelling and bruising and 3 indicating significant swelling and bruising.
- Surgical site swelling and bruising (patient)One week
Subjective measures of patient perceived swelling and bruising will be collected via a patient completed survey given at the first postoperative clinic visit. Surgical site swelling and bruising will be graded on a 4 point scale, with 0 indicating no swelling and bruising and 3 indicating significant swelling and bruising.
- Intraoperative bleedingIntraoperative
Intraoperative bleeding will be assessed using the validated Boezaart Bleeding scale (6 point scale, with 0 indicating no bleeding/cadaveric conditions and 5 indicating severe bleeding/constant suctioning required). Values will be assigned by the attending surgeon and recorded by the research team.
- Intraoperative bleedingIntraoperative
Attending surgeon will score the approximate percent blood saturation of each surgical sponge used in the case. Values from each sponge will be added together for a total cumulative value, with a higher cumulative value indicating a greater amount of intraoperative bleeding.