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Understanding Brain Changes in Lewy Body and Alzheimer's Disease

This observational study aims to understand how the brain, memory, thinking, and movement change in people with Lewy Body Disease, Alzheimer's Disease, and healthy individuals. Researchers will use Magnetic Resonance Imaging (MRI), which looks at brain structure, Electroencephalography (EEG), which measures brain waves, and Electromyography (EMG), which evaluates muscle activity. You may be able to join if you are between 50 and 95 years old, use English as your primary language, and are willing to undergo health and cognitive assessments, brain MRI, and EEG. The study plans to enroll about 90 participants. The current recruitment status is unclear.

Study design
This is an observational study, meaning participants will be studied without receiving any new treatments. It plans to enroll about 90 participants.
What's involved
You would undergo health and cognitive assessments, as well as brain MRI and EEG studies. You will be encouraged to have a study partner familiar with your daily functioning.
Compensation
Not stated in the trial record.
Follow-up
The primary measurements for brain structure (dMRI) and brain waves (EEG) are taken at Baseline, meaning at the start of the study.

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NCT06057909

A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease

Recruiting
Not specifiedAges 50–95Observational
Mayo Clinic
~90 participants
Updated 2026-02-03 on ClinicalTrials.gov
What's tested:Magnetic Resonance ImagingElectroencephalographyElectromyography

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Diffusion-weighted MRI (dMRI)
Measured over Baseline
+1 more outcome measured

Conditions

Lewy Body Disease
Alzheimer Disease
Healthy

Explore related trials

Alzheimer's DiseaseHealthyLewy Body Dementia

Where it's being run

1 sites across 1 states
Arizona1

Study leadership

  • Shannon Chiu, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Sara Dresler
[email protected]
480-301-6279
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Use English as their primary language.
Be willing to undergo health and cognitive assessments, as well as brain MRI and EEG study.
Will be encouraged to have an available study partner (also called a "co-participant") who is familiar with the participant's daily functioning.
This study will be limited to healthy individuals, and patients who have a clinical diagnosis made by a board-certified neurologist of Lewy body disease or Alzheimer disease.
All individuals must be capable of providing informed consent and complying with the trial procedures. Realizing the challenge of obtaining informed consent from cognitively impaired individuals, time is specifically scheduled to foster an informative, supportive interview with the participant and caregiver/legal guardian (typically a spouse or child according to Arizona law and IRB guidelines).
All participants will receive copies of the signed ICFs (including signatures of those obtaining consent).
All participants have the right to withdraw from the study at any time.

Exclusion

Individuals will be excluded if they have significant sensory (visual and hearing) deficits or major medical or psychiatric illnesses which would limit participation.
Participants will also be excluded if they have history of other major neurologic disorders including stroke, epilepsy, meningitis/encephalitis, metabolic or toxic encephalopathy, penetrating or severe closed head injury, brain tumor/other structural lesion, other primary movement disorders (such as essential tremor, dystonia, chorea, multiple system atrophy, progressive supranuclear palsy, corticobasal syndrome).
In addition, as necessitated by the risks of Magnetic Resonance Imaging (MRI), patients who have any type of implanted electrical device (such as a cardiac pacemaker or a neurostimulator including deep brain stimulation), or a certain type of metallic clip in their body (i.e., an aneurysm clip in the brain), are not eligible for participation in the MRI portion of the study. Individuals who experience claustrophobic anxiety will also be excluded from participation.
Women who are or might be pregnant and nursing mothers are not eligible.
If the subject is a woman of childbearing potential, due to unknown risks to the fetus, they must have a pregnancy test. Individuals who have a history metalworking involving cutting processes such as grinding, filing, shaving, and threading, or history of eye injury involving metal, will also be excluded unless they have had prior documented radiological clearance for MRI.

What this trial measures

  • Diffusion-weighted MRI (dMRI)Baseline

    Measures diffusion of water molecules and cellular-level constraints

  • Electroencephalography (EEG)Baseline

    Measures brain-wave activity