Observational Study on PVCs and Myocarditis with ILRs
This observational study is looking at the role of implantable loop recorders (ILRs) in managing Premature Ventricular Contractions (PVCs), which are extra heartbeats that start in the lower chambers of your heart. It also aims to understand if there's a link between PVCs and myocarditis (inflammation of the heart muscle). You might be able to join if you are over 18, have a Medtronic LINQ II ILR, and are willing to give your consent. The study will monitor your heart rhythms and look for signs of myocarditis. Success for this study means identifying unrecognized myocarditis, and seeing if certain treatments can reduce PVCs or improve heart function. The current recruitment status is unclear, but the study plans to enroll about 50 patients.
- Study design
- This is an observational study, meaning researchers will monitor participants without giving them a specific treatment. It will involve about 50 participants.
- What's involved
- Patients will be monitored using ILRs from the time they first experience PVCs and will be followed for 12 months. They will also be evaluated for clinical, biomarker, and radiological evidence of myocarditis.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 12 months to assess the study's primary goals.
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Role of Novel ILR in the Management of PVCs
At a glance
Conditions
Where it's being run
6 sites across 2 statesStudy leadership
- Dhanunjaya Lakkireddy, MD · PRINCIPAL_INVESTIGATOR · Kansas City Heart Rhythm Institute
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Identification of unrecognized myocarditis12 Months
Identification of unrecognized myocarditis in patients presenting PVCs with positive FDG-PET \[fluorodeoxyglucose (FDG)-positron emission tomography (PET)\] scanning.
- Evaluation of efficacy of immunosuppressive therapy - PVC burden reduce12 Months
Evaluation of efficacy of immunosuppressive therapy in patients with NICM with PVCs in reducing PVC burden as compared to their baseline PVC burden.
- Evaluation of efficacy of immunosuppressive therapy - LVEF improvement12 Months
Evaluation of efficacy of immunosuppressive therapy in patients with NICM by documenting improvement in LVEF compared to their baseline LVEF.
- Associated atrial and ventricular arrhythmias12 Months
Assessing incidence of associated atrial and ventricular arrhythmias as detected with ILR recordings in patients with apparently idiopathic PVCs.