Back to search results

19F MRI for Children with Cystic Fibrosis

This study is looking at a new way to see how air moves in the lungs of children using a special MRI scan. It uses a gas called perfluoropropane (PFP) that you breathe in, combined with a 19F-tuned MRI. This technique has not been studied in children before. We are looking for children aged 6 to 17 years old with mild cystic fibrosis (CF) and healthy children in the same age range. The main goal is to see if this type of MRI is practical and acceptable for children. We want to enroll 15 participants, but the current recruitment status is unclear.

Study design
This is an observational study comparing 15 children with cystic fibrosis to healthy children using a new MRI technique.
What's involved
You would undergo a 19F MRI scan after inhaling a special gas. Parental acceptability will be assessed at a single visit on Day 1.
Compensation
Not stated in the trial record.
Follow-up
The study measures participation and completion rates throughout the study, with recruitment planned for two years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06066723

19F MRI in Healthy Children and Children With Mild Cystic Fibrosis Lung Disease

Recruiting
Not specifiedAges 6–17Observational
University of North Carolina, Chapel Hill
~15 participants
Updated 2026-07-02 on ClinicalTrials.gov
What's tested:19F MRI

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Participation rate
Measured over through study completion, recruitment for 2 years
+3 more outcomes measured

Conditions

Cystic Fibrosis in Children

Explore related trials

Cystic FibrosisHealthy

Where it's being run

1 sites across 1 states
North Carolina1

Study leadership

  • Jennifer L Goralski, MD · PRINCIPAL_INVESTIGATOR · UNC Chapel Hill

Who to contact

Jennifer L Goralski, MD
[email protected]
919-445-0331
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

6-17 years old
Non-smoker and non-vaper
Cystic Fibrosis (CF) Group: must have a diagnosis of CF
No use of supplemental oxygen
They must be able to perform spirometry and have stable lung function (within 10% personal best in the last 6 months) and no exacerbations within the past 4 weeks
Baseline forced expiratory volume in 1 second (FEV1) \>80% with ratio of the forced expiratory volume in the first one second to the forced vital capacity of the lung (FEV1:FVC) ratio \>0.7

Exclusion

Healthy volunteers: with any history of chronic lung disease (i.e. asthma)
Active or former smoker with less than 1 year of quitting
Unable to undergo an MRI of the lungs and chest because of contraindications, including:
Injury to the eye involving a metallic object
Injury to the body involving a metallic object
Presence of an implanted drug infusion device that is not MRI safe
Bone growth of fusion simulator
Presence of cochlear, otologic, or ear implant
Shunt (spinal or intraventricular)
Any implant held in place by magnet
Claustrophobia
Unable to tolerate the inhalation of the gas mixture
Facial hair preventing a tight fit of the mask used in the study
Pregnancy
Changes in medication that may affect CF lung disease or lung function in the past 28 days, including experimental therapies

What this trial measures

  • Participation ratethrough study completion, recruitment for 2 years

    The number of eligible participants approached for the study divided by the number who consent to participate.

  • Completion ratethrough study completion, recruitment for 2 years

    The number of consented participants divided by the number of participants who complete each portion of the study.

  • Parental acceptability scoreDay 1, assessed at single visit

    Acceptability questionnaire for guardian; 2 questions, each on a 10 point Likert scale * Implementation: qualitative description of barriers encountered * Practicality: % of participants completing the study with research quality data

  • Child acceptability scoreDay 1, assessed at single visit

    Acceptability questionnaire for participant; 2 questions, each on a 10 point Likert scale * Implementation: qualitative description of barriers encountered * Practicality: % of participants completing the study with research quality data