Study on E-cigarette Withdrawal and Nicotine Patches
This study is looking at how people experience withdrawal when they stop using e-cigarettes, and how nicotine might play a role. Researchers are testing two types of patches: a Transdermal Nicotine Patch (which contains nicotine) and a Placebo Nicotine Patch (which does not contain nicotine). They want to see how these patches affect withdrawal symptoms. You might be able to join if you are between 21 and 55 years old, in good general health, and have used nicotine-containing e-cigarettes daily for at least six months. The study will measure changes in withdrawal symptoms, urges to use e-cigarettes, and your mood to understand the effects. The current status of this study is unclear, and it plans to enroll 150 participants.
- Study design
- This is an interventional study with 150 planned participants. It uses a residential laboratory design where participants are assigned to one of three conditions: active nicotine patch, placebo patch, or no patch.
- What's involved
- You would stay in a residential unit for seven days (1 week) and stop using e-cigarettes. Measurements of withdrawal symptoms, urges, and mood will be taken at baseline and every 4 hours up to 16 hours.
- Compensation
- Not stated in the trial record.
- Follow-up
- Not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Evaluation of the Electronic Cigarette Withdrawal Syndrome
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Justin Strickland, Ph.D. · PRINCIPAL_INVESTIGATOR · Johns Hopkins University
Who to contact
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What this trial measures
- Change in Hughes-Hatsukami Withdrawal ScaleBaseline, every 4 hours up to 16 hours
The Hughes-Hatsukami Withdrawal Scale consists of 13 items presented individually on a 100mm visual analog scale. Higher scores reflect higher withdrawal (worse outcome) \[range 0-32\]. Measures are taken at baseline, 8am, 12pm, 4pm, and 8pm every day during the seven day residential stay.
- Change in Smoking urges as assessed by the Tiffany-Drobes Questionnaire of Smoking Urges (QSU) BriefBaseline, every 4 hours up to 16 hours
The Tiffany-Drobes QSU Brief consists of ten items, each presented on the screen as a phrase centered above seven boxes ranging from (strongly disagree) to (strongly agree). Higher scores reflect higher withdrawal (worse outcome) \[range 0-70\]. Measures are taken at baseline, 8am, 12pm, 4pm, and 8pm every day during the seven day residential stay.
- Change in Positive and Negative Affect Schedule (PANAS)Baseline, every 4 hours up to 16 hours
The PANAS consists of 20 items presented individually on a five-point Likert scale. Higher scores reflect more positive affect and negative affect \[range 0-50\]. Measures are taken at baseline, 8am, 12pm, 4pm, and 8pm every day during the seven day residential stay.
- Change in Conners' Continuous Performance Task (CPT)Baseline, every 4 hours up to 16 hours
On the CPT, participants respond to single letters appearing on their computer screen but are asked to refrain from responding to a specified letter(i.e., the letter X). Higher scores reflect more inattention. Measures are taken at baseline, 8am, 12pm, 4pm, and 8pm every day during the seven day residential stay.
- Change in Memory as assessed by the N-BackBaseline, every 4 hours up to 16 hours
On the n-back, participants decide whether each stimulus in a sequence matches the one that appeared "n" items ago. Higher scores reflect more accuracy. Measures are taken at baseline, 8am, 12pm, 4pm, and 8pm every day during the seven day residential stay.
- Total sleep timeNightly up to seven days
Total time sleeping in minutes measured using actigraphy and unobtrusive EEG.
- Total time spent in Rapid eye movement (REM) sleepNightly up to seven days
Total time sleeping in minutes in REM stage measured using actigraphy and unobtrusive EEG.
- Wake after sleep onset (WASO)Nightly up to seven days
Total number of minutes that a person is awake after having initially fallen asleep measured using actigraphy and unobtrusive EEG.