Intradermal Influenza Vaccination Study

This study is looking at how your body responds to the flu vaccine when given in a different way. Researchers are testing an FDA-approved device called MicronJet 600 to give the Fluzone® Quadrivalent flu vaccine into the skin (intradermal), instead of the usual muscle injection. They will compare this to the standard muscle injection and a saline solution (salt water) control. The main goal is to understand your body's immune response, both in your skin and blood, to the flu vaccine. You can join if you are between 18 and 40 years old, can read and write English, and are willing to follow study procedures. The study is currently recruiting, but the exact status is unclear.

Study design
This interventional study plans to enroll 249 participants. It will compare different ways of giving the flu vaccine.
What's involved
You will have blood and skin samples collected at the start and 28 days after vaccination. You may also have other samples collected and could repeat study visits annually through the 2025-26 flu season.
Compensation
Not stated in the trial record.
Follow-up
You will be followed up to 1 year after vaccination, with primary antibody measurements at Day 0 and Day 28.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06067555

Intradermal Influenza Vaccination

Recruiting
EARLY_PHASE1Ages 18–40InterventionalBasic science
Yale University
~249 participants
Updated 2025-06-19 on ClinicalTrials.gov
What's tested:MicronJetFluzone® QuadrivalentBacteriostatic Saline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in antibody titer concentration to vaccination-Blood
Measured over Day 0 and Day 28
+1 more outcome measured
Vaccine Reaction
1 sites across 1 states
Connecticut1
  • Andrew Johnston · PRINCIPAL_INVESTIGATOR · Yale University

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  • Change in antibody titer concentration to vaccination-BloodDay 0 and Day 28

    Change in antibody titer to vaccination as measured by microneutralization titers at day 0 and day 28 will be correlated with biomarkers in the blood using generalized estimating equations.

  • Change in antibody titer concentration to vaccination-SkinDay 0 and Day 28

    Change in antibody titer to vaccination as measured by microneutralization titers at day 0 and day 28 will be correlated with biomarkers in the skin at baseline using generalized estimating equations.