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Time-Restricted Eating for Short Sleepers

This study is looking at how eating habits affect the heart and metabolism (how your body uses food for energy) in people who usually sleep less than 6.5 hours a night. Researchers want to see if limiting your eating to an 8-hour window each day, called time-restricted eating (TRE), can improve your blood pressure and how your body handles sugar (insulin resistance). You might be able to join if you are between 18 and 45 years old, have a BMI (Body Mass Index) between 25 and 35, and usually eat for more than 14 hours a day. The study is currently ongoing, but the exact status of recruitment is unclear.

Study design
This is an interventional study planning to enroll 100 participants. Participants will be randomly assigned to either follow an 8-hour eating window or continue their usual eating habits.
What's involved
Participants in the time-restricted eating group will be asked to follow an 8-hour eating duration per day for 4 weeks. All participants will continue their habitual sleep patterns.
Compensation
Not stated in the trial record.
Follow-up
Changes in blood pressure and insulin resistance will be measured from the beginning of the study to 4 weeks later.

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NCT06070194

Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period

Recruiting
NAAges 18–45InterventionalBasic science
Pennington Biomedical Research Center
~100 participants
Updated 2026-02-10 on ClinicalTrials.gov
What's tested:Time restricted eating (TRE)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in 24h mean arterial blood pressure (MAP)
Measured over Baseline to 4 weeks
+1 more outcome measured

Conditions

Sleep Deprivation

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Sleep deprivation

Where it's being run

1 sites across 1 states
Louisiana1

Study leadership

  • Prachi Singh, PhD · PRINCIPAL_INVESTIGATOR · Pennington Biomedical Research Institute

Who to contact

Prachi Singh, PhD
[email protected]
225-762-3151
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age: 18-45 years
BMI: 25-35 kg/m2
Habitual sleep duration: ≤6.5 h/night
Habitual eating period: \>14h/day
Absence of chronic health conditions including hypertension (defined as systolic clinical BP of \>140 or diastolic BP of \>90 mmHg or use of BP lowering drugs), dyslipidemia (defined as LDL \>190mg/dL or Triglycerides \>400 mg/dL or use of lipid lowering medications), diabetes (defined as fasting glucose \>126 mg/dL and /or HbA1C \>6.5%, or use of glucose lowering medication), and cardiovascular disease. However, individuals with prehypertension, and/or prediabetes will be allowed to participate.
Individuals with seasonal allergies will also be included.
Women of child-bearing age will be allowed to participate if they agree to use acceptable birth control during the study period.
Must be able to provide written informed consent.
Ability to follow the prescribed eating duration and maintain habitual diet, sleep and physical activity.
Use of certain mediations will be allowed including birth control, second generation antihistamines, antacids, acne-related ointments etc.

Exclusion

Irregular sleep habits / night shift / rotating shift work in past 1 month.
Frequent travel related jet lag.
Pregnant/ breast-feeding/ history of irregular menstrual cycles.
Sleep disorders such as insomnia (defined as Insomnia Severity Index score ≥15), and sleep apnea (overnight oximetry defined oxygen desaturation index of \>10 events/h of sleep).
Presence of excessive daytime sleepiness (defined as Epworth Sleepiness Scale score \>10).
Recent changes in body weight (≥5%) within 3 months.
Uncontrolled depression and /or anxiety, history of psychosis or bipolar disorder.
Uncontrolled depression and/or depression is defined as PHQ-9 score of ≥15 or a positive response for suicidal thoughts (Q9 of the PHQ-9 - any response other than not at all).
Any medication or condition that, in the opinion of the medical investigator, could interfere with the study outcomes or put the subject at risk by participating in the study.
Blood or plasma donation during the past 2 months.

What this trial measures

  • Change in 24h mean arterial blood pressure (MAP)Baseline to 4 weeks

    Change in 24h MAP from pre-intervention to end-intervention. Difference between habitual eating period and TRE will be evaluated.

  • Change in insulin resistanceBaseline to 4 weeks

    Change in insulin resistance from pre-intervention to end-intervention. Insulin resistance will be determined by standard 3h mixed meal tolerance test and calculated as ratio of incremental area under the curve values for insulin and glucose. Difference between habitual eating period and TRE will be evaluated.