Brain Imaging with 18F-FES for ER+ Breast Cancer Brain Metastases
This study is looking at a special type of brain scan called 18F-FES PET/CT in women with estrogen-receptor positive (ER+) breast cancer that has spread to the brain (brain metastases). The goal is to improve how this scan is used to help plan radiation treatment. You would have an additional 18F-FES PET/CT scan before your standard radiation treatment. Researchers will then follow your progress with regular clinical visits and MRI scans for 12 months. This study aims to see how well the 18F-FES PET/CT scan works and if it can help doctors better understand and treat brain metastases. The study plans to enroll 20 participants, but its current recruitment status is unclear.
- Study design
- This is an interventional study, meaning participants will receive a specific intervention (the 18F-FES PET/CT scan). It plans to enroll 20 participants.
- What's involved
- You would undergo an additional 18F-FES PET/CT brain scan, in addition to standard MRI and FDG PET/CT scans. You will also have clinical and MRI assessments for 12 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for a total of 12 months with clinical and MRI assessments.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jana Ivanidze, MD/PhD · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University
Who to contact
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What this trial measures
- Mean SUV3 years
Mean standardized uptake value within a region of interest placed based on MRI findings of suspicious brain lesion.
- Maximum SUV3 years
Maximum standardized uptake value within a region of interest placed based on MRI findings of suspicious brain lesion.
- SUV Ratio3 years
Standardized uptake value ratio of target lesion over reference region.
- Target-to-Background Ratio3 years
Qualitative appearance of lesion delineation on PET.
- Influx (Ki)3 years
Parametric PET analysis results within the same region of interest as that for Maximum SUV.
- Distribution volume (Vt) for scan times3 years
Distribution volume (Vt), measured within the same region of interest as that for Maximum SUV, for scan times ranging between 45 min and 85 min with 5min intervals and corresponding results will be compared to those measured with the full dataset at 90mm.