Dosing of Levothyroxine in Older Individuals with Hypothyroidism

This study is looking at how different doses of levothyroxine sodium, a common medicine for an underactive thyroid (hypothyroidism), affect older adults. You might be able to join if you are 65 or older, have had hypothyroidism for at least six months, and are already taking levothyroxine. The study aims to see if allowing more flexibility in levothyroxine dosing improves your quality of life related to your thyroid. We don't know the current recruitment status for this study.

Study design
This is a randomized, double-blind study involving 228 participants. It compares two different dosing strategies for levothyroxine over six months.
What's involved
You would be part of a study for six months, following a specific levothyroxine dosing strategy. The study will assess your symptoms, mood, sleep, memory, weight, lipids, and bone health.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, Thyroid-Related Quality of Life, is measured at 6 months, which suggests the study duration for participants is at least this long.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06073665

Dosing of LT4 in Older Individuals

Recruiting
PHASE4Ages 65+InterventionalTreatment
University of Pennsylvania
~228 participants
Updated 2026-02-19 on ClinicalTrials.gov
What's tested:Levothyroxine Sodium

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Thyroid-Related Quality of Life Patient-Reported Outcome Quality of Life scale
Measured over 6 months
Hypothyroidism
1 sites across 1 states
Pennsylvania1
  • Anne R. Cappola, M.D., Sc.M. · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

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  • Thyroid-Related Quality of Life Patient-Reported Outcome Quality of Life scale6 months

    22 items, scored 0-100, higher scores indicate worse status