Ketone Ester Consumption and Heart Function in Type 2 Diabetes

This study is looking at how a dietary supplement called C8 Ketone Diester affects heart function in people with Type 2 Diabetes. Researchers want to see if consuming this ketone ester changes how your heart works compared to a placebo (a supplement that looks and tastes the same but doesn't contain the active ingredient). You could be eligible if you are between 18 and 80 years old, have Type 2 Diabetes, and a BMI of 25 or higher. The main goal is to measure changes in your heart's function using special MRI scans. The current status of the study is unclear.

Study design
This is a randomized controlled study with up to 30 participants. You would be randomly assigned to receive either the C8 Ketone Diester or the placebo, then switch to the other treatment after a break.
What's involved
You will consume the C8 Ketone Diester or placebo with a meal, and have images taken before and after. After a two-week break, you will repeat this process with the other treatment.
Compensation
Not stated in the trial record.
Follow-up
Your heart function will be measured at baseline and again after two weeks for each treatment period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06078683

Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

Recruiting
NAAges 18–80InterventionalBasic science
Ohio State University
~30 participants
Updated 2026-04-03 on ClinicalTrials.gov
What's tested:Ketone Ester AcutePlacebo Acute

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Cardiac MRI measures of cardiac function
Measured over Baseline, 2 weeks
Type 2 Diabetes
Ketone Body Metabolism
Ketones, Metabolism
1 sites across 1 states
Ohio1
  • Yuchi Han, MD, MMSc · PRINCIPAL_INVESTIGATOR · Ohio State University

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  • Change in Cardiac MRI measures of cardiac functionBaseline, 2 weeks

    Participants undergo MRI scans, conducted by trained professionals. MRI imaging analyses will determine cardiac function. The images will be analyzed by trained imaging professionals to determine overall change in cardiac function.