Confocal Laser Endomicroscopy for Lung Cancer Diagnosis
This study is looking at a new way to help doctors diagnose lung cancer more accurately. It's for people aged 18 and older who have a suspected lung lesion (an abnormal area) that doctors think might be cancer. The study compares a standard procedure called conventional diagnostic bronchoscopy with a new technique called Needle Based Confocal Laser Endomicroscopy (nCLE). nCLE uses a special camera on a needle to get real-time, microscopic images of the lung tissue during the bronchoscopy. The main goal is to see if adding nCLE helps doctors get a more definitive diagnosis from the bronchoscopy. This study plans to enroll 208 participants.
- Study design
- This is an interventional study, meaning participants will receive a specific intervention. It is a randomized clinical trial, which means participants will be assigned by chance to one of the study groups.
- What's involved
- Participants will undergo a bronchoscopy procedure. The study will follow participants for up to 6 months after their bronchoscopy.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed up to 6 months after their bronchoscopy procedure.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Confocal Laser Endomicroscopy VERification
At a glance
Conditions
Where it's being run
5 sites across 5 statesStudy leadership
- Jouke Annema, Prof. dr. · PRINCIPAL_INVESTIGATOR · Amsterdam UMC
Who to contact
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What this trial measures
- Diagnostic yield (intermediate definition)After all patients have been included and followed up to 6 months after bronchoscopy (expected total time frame 2 years)
Diagnostic yield (defined as the proportion of patients in whom the bronchoscopic procedure results in a definitive diagnosis \[either malignant, specific benign or non-specific benign confirmed as benign in follow-up\], relative to the total number of patients that underwent the diagnostic bronchoscopic procedure). If patients with multiple lesions are included, the diagnostic yield will be computed per nodule.