Ketogenic Diet vs. Mixed Diet for Heart Failure

This study is comparing two different diets for people with heart failure that has preserved ejection fraction (meaning your heart still pumps blood normally). You would either follow a ketogenic diet or a low-fat mixed diet. Researchers want to see if one diet helps improve your ability to exercise. To join, you need to be between 18 and 80 years old, have heart failure with normal pumping function, and be willing to be assigned to either diet. The study aims to enroll 90 participants. The current recruitment status is unclear.

Study design
This is an interventional study where participants will be randomly assigned to one of two diets. It plans to enroll 90 participants.
What's involved
For the first 6 weeks, all your food will be prepared and delivered. After that, you'll receive educational materials and coaching for about 20-22 weeks to help you maintain the diet. You will also have sensors applied at different times to monitor ketone and glucose levels, and your weight, blood pressure, heart rate, and activity will be monitored.
Compensation
All foods and/or groceries will be provided at no cost for the first six weeks of the study.
Follow-up
Your maximal exercise performance will be measured at baseline, 6 weeks, and at the end of the study (26 weeks).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06081543

Ketogenic Diet vs Mixed Diet in Patients With Heart Failure

Recruiting
NAAges 18–80InterventionalBasic science
Ohio State University
~90 participants
Updated 2026-07-23 on ClinicalTrials.gov
What's tested:Ketogenic dietLow-fat Mixed diet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in maximal exercise performance
Measured over baseline, 6 weeks, and end of the study (26 weeks)
Heart Failure With Preserved Ejection Fraction
1 sites across 1 states
Ohio1
  • Yuchi Han, MD, MMSc · PRINCIPAL_INVESTIGATOR · Ohio State University

Opens a ready-to-send draft in your own email app — review before sending.

  • Changes in maximal exercise performancebaseline, 6 weeks, and end of the study (26 weeks)

    Participants will undergo VO2 max testing, conducted by trained professionals. VO2 max testing analyses will determine changes in maximal exercise performance