Computerized Interventions for Stress in Cannabis Users

This study is evaluating two brief, computerized interventions for stress in young adults (ages 18-30) who use cannabis regularly and have Cannabis Use Disorder (CUD). One intervention, called Emotional Engagement Distress Tolerance Intervention, helps you build tolerance to difficult emotions. The other, Health Education Intervention, focuses on healthy habits for managing stress. Researchers want to see if these interventions can reduce how much distress you feel and improve your cannabis use. To join, you must have a CUD diagnosis, use cannabis almost daily, and have high levels of distress intolerance (difficulty handling upsetting feelings). Your urine will be tested for THC. The study aims to enroll 80 participants, but its current status is unclear.

Study design
This is an interventional study comparing two behavioral interventions. It plans to enroll 80 participants.
What's involved
You will participate in a 2.5-hour computerized intervention with smartphone support. You will also complete questionnaires immediately after the intervention, and then 10 days, 20 days, one month, and four months later.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for four months after the intervention session.

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NCT06085222

Evaluation of a Brief Computerized and Smart Phone-based Intervention for Stress in Regular Cannabis Users

Recruiting
NAAges 18–30InterventionalTreatment
Florida State University
~80 participants
Updated 2025-09-22 on ClinicalTrials.gov
What's tested:Emotional Engagement Distress Tolerance InterventionHealth Education Intervention

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Therapy Evaluation Questionnaire
Measured over Immediately after intervention session
+12 more outcomes measured
Cannabis Use Disorder
1 sites across 1 states
Florida1
  • Richard J Macatee, PhD · PRINCIPAL_INVESTIGATOR · Florida State University
Zoe Howell Project Coordinator, BS
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Eligibility criteria

Inclusion

Cannabis is the primary substance of abuse.
Clinical-level Distress intolerance Index score.
Current Cannabis Use Disorder diagnosis.
Near-daily to daily cannabis use in past-month and past 3 months.
Positive urine screen for THC
Detectable skin conductance level
Owns a smart phone
Primary smoked/vaporized delta-9 or delta-8 THC user

Exclusion

Presence of acute/major psychiatric disturbance
Current pregnancy
Change in psychotropic medication within the past month
Concurrently receiving treatment for cannabis use
Concurrently receiving dialectical behavior therapy or exposure-based therapy for emotional disorders
Planning to immediately quit using cannabis
EEG contraindications
Kidney disease
  • Therapy Evaluation QuestionnaireImmediately after intervention session

    acceptability/feasibility (credibility subscale range 3-27; expectancy item range 0%-100%; higher scores indicate better outcome)

  • Treatment Satisfaction QuestionnairePost-Intervention (20 days after intervention session)

    acceptability/feasibility (range 0-84; higher scores indicate better outcome)

  • Change in perceived distress intolerance from baseline through follow-upBaseline, Mid-Intervention (10 days after intervention session), Post-Intervention (20 days after intervention session), One-Month Follow-up, Four-Month Follow-up

    Distress Intolerance Index (range 0-40; higher scores indicate worse outcome) to assess perceived distress intolerance via self-report

  • Change in behavioral distress intolerance from baseline through follow-upBaseline, Mid-Intervention (10 days after intervention session), Post-Intervention (20 days after intervention session), One-Month Follow-up, Four-Month Follow-up

    Mirror-Tracing Persistence Task to assess behavioral distress intolerance via computerized task

  • Change in laboratory stress-induced cannabis craving from baseline through post-interventionBaseline, Post-Intervention (20 days after intervention session)

    Change in Marijuana Craving Questionnaire (range 11-77; higher scores indicate worse outcome) after Mannheim Multicomponent Stress Test at post-intervention compared to baseline

  • Change in laboratory stress-induced neural reactivity to cannabis cues (assessed via the electroencephalography [EEG]-recorded late positive potential) from baseline through post-interventionBaseline, Post-Intervention (20 days after intervention session)

    Change in Late Positive Potential to Cannabis Cues after Mannheim Multicomponent Stress Test at post-intervention compared to baseline

  • Change in real-world stress-elicited cannabis use from baseline to post-interventionBaseline, Mid-Intervention (10 days after intervention session), Post-Intervention (20 days after intervention session)

    Change in stress-\>cannabis use slopes derived from ecological momentary assessment from baseline through post-intervention

  • Change in cannabis use frequency from baseline through follow-upBaseline, Post-Intervention (20 days after intervention session), One-Month Follow-up, Four-Month Follow-up

    Change in cannabis use frequency (measured via timeline follow-back) from baseline through four-month follow-up

  • Change in urine tetrahydrocannabinol [THC] metabolite concentration from baseline through follow-upBaseline, Mid-Intervention (10 days after intervention session), Post-Intervention (20 days after intervention session), One-Month Follow-up, Four-Month Follow-up

    Change in urinary THC metabolite concentration (measured via ultra high performance liquid chromatography \[UHPLC\]) from baseline through four-month follow-up

  • Change in self-reported cannabis use problems from baseline through follow-upBaseline, Post-Intervention (20 days after intervention session), One-Month Follow-up, Four-Month Follow-up

    Change in Marijuana Problems Scale (range 0-38; higher scores indicate worse outcome) from baseline through follow-up

  • Change in Cannabis Use Disorder symptoms from baseline through follow-upBaseline, Four-Month Follow-up

    Change in interviewer-assessed Cannabis Use Disorder criteria (range 0-11; higher scores indicate worse outcome) from baseline to four-month follow-up

  • Change in Cannabis Demand from baseline to post-interventionBaseline, Post-Intervention (20 days after intervention session)

    Change in Omax, Breakpoint, and Elasticity derived from Marijuana Purchase Task (higher OMax/Breakpoint and lower Elasticity indicate worse outcome) at post-intervention compared to baseline

  • Change in cannabis use quantity from baseline to post-interventionBaseline, Post-Intervention (20 days after intervention session), One-Month Follow-up, Four-Month Follow-up

    Change in cannabis use quantity (measured via timeline follow-back) from baseline through four-month follow-up