This observational study is looking for better ways to detect lung problems early in people who have received an allogeneic hematopoietic stem cell transplant (HSCT). An HSCT is a type of stem cell transplant where you receive cells from a donor. Sometimes, after this procedure, your immune system can attack healthy lung cells, leading to inflammation and scarring. Researchers will use imaging tests of your chest and a procedure called bronchoalveolar lavage (BAL), where a small sample of fluid is taken from your lungs, to identify these lung issues sooner. The goal is to see if these preemptive assessments can help identify lung injury due to infection or other immune reactions after HSCT. You may be eligible if you are between 5 and 70 years old and are having an HSCT as part of another NIH study.

Study design

This is an observational study with a planned enrollment of 40 participants. It is designed to look for early signs of lung inflammation.

What's involved

Participants will undergo tests before their HSCT, including chest imaging and bronchoalveolar lavage (BAL). The primary endpoint is measured at 30 months.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint for detecting lung injury is measured at 30 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.