Hospital Protocol for Emergency Stroke Evaluation and Transfer (HI-SPEED)

This study is testing a new set of procedures called the HI-SPEED Protocol to help hospitals quickly evaluate stroke patients and transfer them to specialized centers if needed. Many stroke patients first go to a local hospital, but some require more advanced care at a different hospital. The HI-SPEED Protocol aims to speed up the "Door-In-Door-Out" (DIDO) time, which is how long it takes for a patient to be evaluated and transferred from the first hospital. This could help more patients get advanced treatments in time. The study is looking at how well this protocol works in reducing DIDO time for patients with acute ischemic stroke (a stroke caused by a blood clot) or hemorrhagic stroke (a stroke caused by bleeding). It plans to include 900 participants aged 18 and older who have been diagnosed with these types of stroke. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 900 participants. It is testing a behavioral intervention called the HI-SPEED Protocol.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, DIDO time, is measured at baseline for acute ischemic stroke patients.

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NCT06094478

Hospital Implementation of a Stroke Protocol for Emergency Evaluation and Disposition

Recruiting
NAAges 18+InterventionalHealth services
University of Chicago
~900 participants
Updated 2026-05-20 on ClinicalTrials.gov
What's tested:HI-SPEED Protocol

At a glance

Recruiting sites
8 of 8 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
DIDO time in acute ischemic stroke patients
Measured over Baseline
Stroke, Acute
Ischemic Stroke, Acute
Hemorrhagic Stroke
8 sites across 8 states
Connecticut1
Florida1
Georgia1
Illinois1
Michigan1
New York1
Ohio1
Utah1
  • Shyam Prabhakaran, MD, MS · PRINCIPAL_INVESTIGATOR · University of Chicago
  • Jane Holl, MD, MPH · PRINCIPAL_INVESTIGATOR · University of Chicago

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Eligibility criteria

Inclusion

Age \>=18 years
Final diagnosis: AIS, ICH, or SAH

Exclusion

Final diagnosis: TIA or stroke NOS
Age \<18 years
Comfort care measures on day 0 or 1
Left hospital against medical advice
Enrolled in clinical trial related to stroke that is competing with this study
  • DIDO time in acute ischemic stroke patientsBaseline

    Time from ED arrival to ED departure prior to transfer to a comprehensive stroke center among ischemic stroke patients