Long COVID Brain Fog: Cognitive Rehabilitation Trial
This study is looking at two different ways to help adults with long COVID who are experiencing brain fog and mild to moderate thinking problems. One approach uses computer "games" to improve how quickly you process information, along with training on everyday tasks and strategies to use what you learn in daily life. The other approach, called Constraint-Induced Cognitive Therapy (CICT), combines these elements with a non-invasive form of vagus nerve stimulation (taVNS). The goal is to see if these treatments can improve your ability to perform daily activities. You might be able to join if you've had COVID more than three months ago, have brain fog and some cognitive impairment, and can travel to the lab. The study plans to enroll 30 participants.
- Study design
- This interventional study aims to enroll 30 participants to compare two different cognitive rehabilitation approaches for long COVID brain fog.
- What's involved
- Participants will receive various behavioral trainings, including computer-based games and in-lab training on daily tasks. After treatment, there will be four follow-up phone calls over the first month.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will have four follow-up phone calls in the first month after completing training, with each call about a week apart.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Long COVID Brain Fog: Cognitive Rehabilitation Trial
At a glance
Conditions
NCT06095297
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Alabama at Birmingham
Birmingham, Alabamastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Gitendra Uswatte, PhD · PRINCIPAL_INVESTIGATOR · Professor of Psychology, University of Alabama at Birmingham
Who to contact
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Inclusion
Exclusion
What this trial measures
- Canadian Occupational Performance Measure (COPM)Change from Day 30 to Day 60, i.e., from Pre- to Post-treatment
The COPM is a standard, validated, trans-diagnostic, patient-centered structured interview which is commonly used to measure the real-world outcome of rehabilitation procedures that span both motor and cognitive functions after stroke. The Performance Scale assesses how well a participant performs five activities in their daily life, i.e., outside the lab, that are important to the participant. Activities, for this purpose, will be restricted to those with an important cognitive component ,i.e., IADL. The 10-point response scale ranges from 1 (not able to do the activity at all) to 10 (able to do the activity extremely well). Performance Scale scores from the participant will be the primary outcome.