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Nicotine Addiction Threshold Study

This study is looking for adults aged 21 to 59 who smoke to help researchers understand how different amounts of nicotine affect them. You would receive nicotine or saline (saltwater) through a pump. The main goal is to see if you can correctly tell the difference between nicotine and saline. Researchers also want to learn about the pleasant feelings and choices you make when given nicotine. The study plans to enroll 45 participants, but its current status is unclear.

Study design
This interventional study involves comparing different doses of nicotine to saline in smokers. It plans to enroll 45 participants.
What's involved
You would have an Adaptation Session to get familiar with the study, followed by 4 Test Days. On each Test Day, you would sample nicotine and saline, then complete trials to discriminate between them and choose between them.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, correctly identifying nicotine, is measured for up to 8 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06096714

Addictive Threshold of Nicotine

Recruiting
EARLY_PHASE1Ages 21–59InterventionalHealth services
Yale University
~45 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:NicotineSaline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
correctly identifying nicotine
Measured over up to 8 weeks

Conditions

Smoking Addiction

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Addictive spending behavior

Where it's being run

1 sites across 1 states
Connecticut1

Who to contact

Stacy Minnix, B.S
[email protected]
203-932-5711
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Eligibility criteria

Inclusion

to contact their primary care provider when necessary.
Adults, aged 21 to 59 years. Individuals less than 21 will be excluded because the minimum age for purchasing tobacco products is 21 in our state. The upper age is set at 59 because there are no previous IV nicotine studies that enrolled smokers over the age of 59.
Smoking at least for one year and more frequently than once a week, smoking status confirmed with a semi-quantitative urine nicotine test. Smokers will be stratified based on the level of dependence, assessed with the FTND scores (Heatherton et al. 1991) (low or no dependence 4 and moderate or high level of dependence 5.
In good health as verified by medical history, screening examination, and screening laboratory tests.
For women, report using acceptable birth control methods.

Exclusion

History of major medical or psychiatric disorders that the physician investigator deems as contraindicated for the participant to be in the study
regular current use of certain psychotropic medications (such as mood stabilizers, antipsychotics, or anxiolytics being prescribed to treat bipolar disorder, psychosis or anxiety spectrum disorders, respectively)
current untreated alcohol or substance use disorder for any other recreational or prescription drugs other than nicotine
for women, pregnant as determined by pregnancy screening, or breastfeeding
seeking (or undergoing) treatment for tobacco dependence or smoking.

What this trial measures

  • correctly identifying nicotineup to 8 weeks

    Reinforcement will be assessed with the percentage of nicotine doses chosen during the Choice trials (out of 16), 4 choices per day over four days.