PET Imaging Study for Parkinson's, MSA, and Dementia with Lewy Bodies

This study is looking at a special imaging agent called [11C]SY08. Researchers want to see how this agent moves through the brain and if it can help detect alpha synuclein (αS) aggregates, which are clumps of protein linked to certain brain conditions. This is being studied in people with Parkinson's disease (PD), Multiple System Atrophy (MSA), Dementia with Lewy Bodies (DLB), and healthy volunteers. The main goal is to understand how [11C]SY08 works in the brain. You may be able to join if you are between 50 and 80 years old, can speak English, and can give your consent. The study plans to enroll 40 participants.

Study design
This interventional study plans to enroll 40 participants, including those with Parkinson's disease, Multiple System Atrophy, Dementia with Lewy Bodies, and healthy controls.
What's involved
The study involves evaluating brain uptake of [11C]SY08, measured at up to 120 minutes.
Compensation
Not stated in the trial record.
Follow-up
Brain uptake of the imaging agent will be evaluated for up to 120 minutes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06098612

PET Imaging Evaluation of [11C]SY08

Recruiting
EARLY_PHASE1Ages 50–80InterventionalBasic science
Massachusetts General Hospital
~40 participants
Updated 2025-12-24 on ClinicalTrials.gov
What's tested:C11-SY08

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
brain uptake evaluation
Measured over up tp 120 minutes
Parkinson's Disease
Multiple System Atrophy
Dementia With Lewy Bodies
Healthy Controls
1 sites across 1 states
Massachusetts1

Opens a ready-to-send draft in your own email app — review before sending.

  • brain uptake evaluationup tp 120 minutes

    The investigators will use SUV or SUV to evaluate brain uptake