LIVELONG Study: Ablative Therapy for Gastrointestinal Cancers

This study, called LIVELONG, is looking at how well adding local ablative therapies (treatments that destroy cancer cells in a specific area) works for certain gastrointestinal cancers that have started to grow again in a limited way, even while you're on other treatments. It's for people with small bowel, colorectal, appendiceal, biliary, or gallbladder cancers. The study will use either Stereotactic Ablative Radiotherapy (SABR) or interventional radiology (IR) ablation therapy. The main goal is to see if your disease is controlled three months after starting these local treatments. The study is currently unclear on its recruitment status and plans to enroll 300 participants.

Study design
This is a phase 2 study involving 300 participants at a single site. It is designed to evaluate the clinical benefit of adding local ablative therapies to ongoing systemic therapy.
What's involved
Participants will receive ablative local therapy in addition to their current systemic therapy. They will be followed for up to 5 years after the ablative local therapy.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 5 years after receiving ablative local therapy.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06101277

Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG)

Recruiting
NAAges 18+InterventionalTreatment
University of California, Davis
~300 participants
Updated 2026-07-02 on ClinicalTrials.gov
What's tested:Ablative local therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants with controlled disease
Measured over 3 months from the first day of ablative local therapy
Small Bowel Cancer
Colorectal Cancer
Appendiceal Cancer
Biliary Cancer
Gall Bladder Cancer
Intrahepatic Cholangiocarcinoma
Extrahepatic Cholangiocarcinoma
Oligoprogressive
1 sites across 1 states
California1
  • Edward Kim, MD, PhD · PRINCIPAL_INVESTIGATOR · University of California, Davis

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  • Number of participants with controlled disease3 months from the first day of ablative local therapy

    Number of participants with controlled disease at 3 months, defined as continuation in systemic cancer therapy without any changes or permanent discontinuation for 3 months following first day of ablative local therapy