LAYOVER Study: Ablative Therapy for Oligo-Progressive Genitourinary Cancers

This study, called LAYOVER, is looking at how well adding local ablative therapies (like Stereotactic Ablative Radiotherapy (SABR) or interventional radiology (IR) ablation therapy) to ongoing systemic (whole-body) treatment works for people with certain genitourinary cancers that are "oligo-progressive." This means the cancer has progressed in a limited number of spots. You might be able to join if you have prostate cancer, urothelial carcinoma (bladder cancer), or renal cell carcinoma (kidney cancer). The study aims to see if this approach helps control the disease for at least 3 months. The study plans to enroll 150 participants, but its current status is unclear.

Study design
This is a single-site, phase 2 pragmatic study that will enroll 150 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will receive ablative local therapy in addition to their systemic therapy. You will be followed for up to 5 years after the ablative local therapy.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 5 years after receiving ablative local therapy.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06101290

Locally Ablative TherapY in Oligo-ProgressiVe GEnitourinary TumoRs (LAYOVER)

Recruiting
NAAges 18+InterventionalTreatment
University of California, Davis
~150 participants
Updated 2026-06-30 on ClinicalTrials.gov
What's tested:Ablative local therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants with controlled disease
Measured over 3 months from the first day of ablative local therapy
Prostate Cancer
Oligoprogressive
Urothelial Carcinoma
Renal Cell Carcinoma
1 sites across 1 states
California1
  • Mamta Parikh, MD, MS · PRINCIPAL_INVESTIGATOR · University of California, Davis

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  • Number of participants with controlled disease3 months from the first day of ablative local therapy

    Number of participants with controlled disease at 3 months, defined as continuation in systemic cancer therapy without any changes or permanent discontinuation for 3 months following first day of ablative local therapy