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Observational Study of Endometriosis Pain

This study aims to understand the factors that contribute to pelvic pain in women, both with and without endometriosis. Researchers will also look at how pain and hormone levels change after surgery to remove endometriosis lesions (growths). They hope to identify what predicts pain reduction after surgery. You may be eligible if you are a woman between 12 and 45 years old with pelvic pain, and are scheduled for laparoscopic surgery for endometriosis diagnosis or treatment. The study involves psychophysical assessments (tests of how you experience pain), and collecting blood, urine, and saliva samples to measure hormone levels. During surgery, biopsies (small tissue samples) will be taken from endometriosis lesions and healthy tissue. The study will track your pain ratings and estrogen levels at the start, and then at 3 months, 6 months, and 1 year after surgery.

Study design
This is an observational study with a planned enrollment of 120 women. It is not a treatment study, but rather aims to understand pain and hormone changes over time.
What's involved
You will have a 2.5-hour study visit for pain assessments and to complete questionnaires. Blood, urine, and saliva samples will be collected, and tissue biopsies will be taken during your scheduled surgery.
Compensation
Not stated in the trial record.
Follow-up
Your pain ratings and estrogen levels will be followed up at 3 months, 6 months, and 1 year after surgery.

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NCT06101303

Endometriosis Pain

Recruiting
Not specifiedAges 12–45Observational
Washington University School of Medicine
~120 participants
Updated 2026-07-13 on ClinicalTrials.gov
What's tested:Psychophysical assessmentPsychophysical assessments of experimental painBlood, urine and saliva samplesBiopsy and surgery-related data.

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pain ratings of clinical pain
Measured over Baseline and follow up (3 months, 6 months and 1 year after surgery)
+3 more outcomes measured

Conditions

Pelvic Pain
Endometriosis

Explore related trials

EndometriosisPelvic Pain

Where it's being run

1 sites across 1 states
Missouri1

Study leadership

  • Hadas Nahman-Averbuch, PhD · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine

Who to contact

Alana McMichael, MA
[email protected]
314-273-6194
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients with pelvic pain with and without endometriosis scheduled for an operative laparoscopic surgery for endometriosis diagnosis and/or treatment
Age 12-45
Females

Exclusion

Pregnancy
Planned hysterectomy or oophorectomy
Co-occurring vaginismus and/or vulvodynia
For patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health

What this trial measures

  • Pain ratings of clinical painBaseline and follow up (3 months, 6 months and 1 year after surgery)

    Rating the pain intensity level using a numerical pain scale (0-100) or visual analog scale

  • Estrogen levelsBaseline

    systemic estrogen level and local estrogen level from the lesion

  • Estrogen receptor expression in the lesionBaseline

    analyzing the levels of estrogen receptor expression in the endometriosis lesion

  • Conditioned pain modulation (CPM) responseBaseline and follow up (3 months, 6 months and 1 year after surgery)

    The CPM paradigm assesses endogenous inhibitory pain modulation efficiency. CPM testing includes the application of a "test" stimulus without conditioning (control run, pressure pain thresholds) and a subsequent application of the same test stimulus together with a conditioning stimulus (conditioning run, a 60 second of foot immersion in cold water). The CPM response is the difference in the pressure pain thresholds between the control and the conditioning runs.