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Cognitive Control Training for Childhood OCD

This study is testing a child-friendly video game called Cognitive Control Training (AKL-T01) for children aged 8 to 12 with Obsessive-Compulsive Disorder (OCD). The goal is to see if this at-home iPad program, which focuses on attention, memory, and impulse control, can help improve OCD symptoms. You would play the game for 25 minutes a day, 5 days a week, for four weeks. Researchers will use a test called the NIH Toolbox Cognition Battery to measure changes in cognitive skills before, during, and after the training. The study aims to enroll 60 children, but its current status is unclear.

Study design
This is an interventional study with a planned enrollment of 60 children. It is designed to see if Cognitive Control Training (AKL-T01) can improve cognitive control in children with OCD.
What's involved
Participants will use an iPad for Cognitive Control Training (AKL-T01) for 25 minutes a day, 5 days a week, for 4 weeks. They will complete the NIH Toolbox Cognition Battery at the beginning, after 2 weeks, and after 4 weeks. MRI scans will be done before and after the training.
Compensation
Not stated in the trial record.
Follow-up
Participants will be offered a 12-week course of Cognitive Behavioral Therapy (CBT) or community referrals after the 4-week Cognitive Control Training.

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NCT06102941

Cognitive Control Targets for the Treatment of Obsessive Compulsive Disorder in Young Children

Recruiting
NAAges 8–12InterventionalTreatment
Columbia University
~60 participants
Updated 2025-11-06 on ClinicalTrials.gov
What's tested:Cognitive Control Training (CT)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
NIH Toolbox Cognition Battery
Measured over Baseline, 2-week follow-up (mid-training), and 4-week follow-up (post-training)

Conditions

Obsessive-Compulsive Disorder in Children

Explore related trials

Obsessive Compulsive Disorder

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Rachel Marsh · PRINCIPAL_INVESTIGATOR · Columbia University

Who to contact

Marsh Lab
[email protected]
646-774-5868
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Ages between 8 and 12 years;
Clinically significant OCD as the principal problem. This is defined as follows: they must meet DSM-V criteria for OCD as assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime Version (K-SADS-PL). OCD must be the primary source of interference and distress (based on clinical evaluation with K- SADS-PL and Children's Yale-Brown Obsessive Compulsive Scale (C-YBOCS) and they must have clinically significant symptoms (i.e., C-YBOCS) ≥ 16;
Not on psychotropic medication (either treatment-naïve or free of psychotropic medication for at least three months) and not receiving current psychotherapy for OCD;
Ability to tolerate a treatment-free period (i.e., no treatment other than study CBT);
Capacity to provide informed assent

Exclusion

Current or past diagnosis of major depressive disorder, PTSD, substance/alcohol abuse, psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, substance/alcohol dependence, or any other Axis I disorder not listed above;
Active suicidal ideation;
Females who are pregnant or nursing;
Any major medical or neurological problem (e.g., unstable hypertension, seizure disorder, head trauma); -Positive urine screen for illicit drugs;
Presence of metallic device or dental braces;
IQ \<80;

What this trial measures

  • NIH Toolbox Cognition BatteryBaseline, 2-week follow-up (mid-training), and 4-week follow-up (post-training)

    Standardized Cognitive Function Composite Scores will be derived from the following NIH Toolbox tasks: 1) Flanker inhibitory control and attention task, 2) Dimensional Change Card Sort (DCCS) test of set-shifting function, 3) List of Working Memory Test, and 4) Pattern Comparison Processing Speed Test.