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Hyperpolarized 13C-pyruvate Metabolic MRI for Traumatic Brain Injury

This study is looking at a new way to use MRI scans to understand early brain changes after a head injury. It uses a special injection called Hyperpolarized 13C-Pyruvate (13C) along with an MRI to see how your brain uses energy. The goal is to see if this method can help doctors better diagnose traumatic brain injury (TBI) by comparing results from people with TBI, people with subarachnoid hemorrhage (SAH - bleeding around the brain), and healthy volunteers. The study is open to adults aged 18 to 80 who have had a recent head injury and are able to have an MRI. Success will be measured by how well the MRI can show the conversion of pyruvate to other substances in the brain. The study plans to enroll up to 15 participants and is currently unclear on its recruitment status.

Study design
This is an interventional study planning to enroll up to 15 participants, including those with TBI, SAH, and healthy volunteers.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken within two years after you join the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06103201

Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury

Recruiting
PHASE1Ages 18–80InterventionalDiagnostic
University of Maryland, Baltimore
~15 participants
Updated 2025-05-11 on ClinicalTrials.gov
What's tested:Hyperpolarized 13C-Pyruvate

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Measures of conversion of pyruvate to lactate (apparent conversion rate constant kPL, lactate-to-pyruvate ratio) and pyruvate to bicarbonate (apparent conversion rate constant kPB, bicarbonate-to-pyruvate ratio)
Measured over within two years post enrollment

Conditions

Traumatic Brain Injury
Subarachnoid Hemorrhage

Explore related trials

Subarachnoid HemorrhageTraumatic Encephalopathy

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Dirk Mayer, Dr. rer. nat. · PRINCIPAL_INVESTIGATOR · University of Maryland, Baltimore

Who to contact

Rosy Linda Njonkou Tchoquessi
[email protected]
410-706-0943
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

History of acute head injury with or suspected non-penetrating acute TBI
Suitable to undergo contrast-enhanced MRI
Negative serum pregnancy test

Exclusion

Inability to undergo MRI scan
Inability to receive IV MRI contrast agents secondary to severe reaction or renal insufficiency
Positive pregnancy test

What this trial measures

  • Measures of conversion of pyruvate to lactate (apparent conversion rate constant kPL, lactate-to-pyruvate ratio) and pyruvate to bicarbonate (apparent conversion rate constant kPB, bicarbonate-to-pyruvate ratio)within two years post enrollment

    To assess the differences between the three patient groups