129 Xenon MRI for Pulmonary Arterial Hypertension (PAH)
This study is looking at how a special type of MRI, called 129Xe MRI, can help doctors understand and track pulmonary arterial hypertension (PAH). PAH is a condition where blood pressure in the arteries of your lungs is too high. Researchers want to see if 129Xe MRI can show differences between common types of PAH and how well treatments are working over time. You might be able to join if you are 18-75 years old and have Idiopathic PAH or PAH linked to a connective tissue disease. The study will measure changes in your lung blood vessels using the 129Xe MRI over one year to see if it's a good way to monitor the disease.
- Study design
- This is an observational study involving 20 participants, split into two groups of 10 each, to compare different types of PAH.
- What's involved
- You would undergo 129Xe MRI/MRS scans at baseline, 3 months, 6 months, and 12 months. Standard medical assessments like labs, echocardiograms, and 6-minute walk tests will also be collected at these times.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 12 months to track changes in their condition.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Fawaz Alenezi, MD · PRINCIPAL_INVESTIGATOR · Duke Univeristy
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Pulmonary Vascular Remodeling1 year
The primary endpoint for this trial will be the change in defect + low percentage of RBC signal on hyperpolarized 129Xe MRI from baseline to 12 months