Studying Brain Activity and Satiety with rTMS
This study is exploring how a part of the brain called the cerebellum affects feelings of fullness (satiety) in healthy individuals. Researchers are using a non-invasive technique called repetitive Transcranial Magnetic Stimulation (rTMS). This involves placing a coil on the scalp to create a magnetic field that can change brain activity. You might receive either active rTMS or a sham (inactive) rTMS. The study aims to see how rTMS changes brain activity in the cerebellum and another area called the ventral striatum, and how it affects your desire for food. To join, you should be a healthy individual between 18 and 65 years old with a BMI between 20-35.0 kg/m2. The study plans to enroll 150 participants, but its current recruitment status is unclear.
- Study design
- This is an interventional study planning to enroll 150 healthy participants. It compares active repetitive Transcranial Magnetic Stimulation (rTMS) with sham rTMS.
- What's involved
- You will have an initial screening, an MRI scan, and then two separate testing sessions. Each testing session involves MRI imaging and food intake assessments before and after rTMS.
- Compensation
- Not stated in the trial record.
- Follow-up
- Brain activity and food reward are measured up to 60 minutes after rTMS at each of the two main study visits.
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Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
At a glance
Conditions
Where it's being run
2 sites across 1 statesStudy leadership
- Laura Holsen, PhD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in BOLD response in the cerebellum30 minutes pre-TMS and 30 minutes post-TMS, at each of two main study visits (fed, fasted)
Change in functional activation of the cerebellum will be assessed before (pre-TMS) and after (post-rTMS) rTMS stimulation, measured separately at the fed visit and at the fasted visit.
- Change in BOLD response in the ventral striatum30 minutes pre-TMS and 30 minutes post-TMS, at each of two main study visits (fed, fasted)
Change in functional activation of the ventral striatum will be assessed before (pre-TMS) and after (post-rTMS) rTMS stimulation, measured separately at the fed visit and at the fasted visit.
- Change in food reward valuationup to 60 minutes pre-TMS and up to 60 minutes post-TMS, at each of two main study visits (fed, fasted)
Change in food reward valuation of high-calorie foods will be assessed using the Willingness to Pay task, measured before (pre-TMS) and after (post-rTMS) rTMS stimulation, measured separately at the fed visit and at the fasted visit.
- Ad libitum snack food intakebaseline, up to 60 minutes post-TMS at each of two main study visits (fed, fasted)
Change in total caloric intake during the ad libitum snack food session will be assessed at the baseline visit and after (post-rTMS) rTMS stimulation, the latter measured separately at the fed visit and at the fasted visit.