EBUS-TBNA vs. Cryobiopsy for Lung Cancer Tissue Analysis

This study is comparing two ways to collect tissue samples for lung cancer: Endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) and Transbronchial Mediastinal Cryobiopsy. The goal is to see which method is better at getting enough tissue for next-generation sequencing (NGS) tests, which help doctors understand your cancer better. You might be able to join if you have a suspected lung cancer lesion that can be biopsied and if initial tests show cancer cells. The study is looking for 250 participants and is currently unclear on its recruitment status. Success for this study means finding a method that provides enough tissue for these important genetic tests.

Study design
This is an interventional study comparing two biopsy procedures. It plans to enroll 250 participants.
What's involved
You would undergo a bronchoscopy procedure. During this procedure, you would be randomly assigned to either continue with an EBUS-TBNA needle or switch to a cryoprobe for tissue sampling.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome of sufficient tissue for testing will be measured up to 12 months after the procedure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06105801

EBUS-TBNA vs Transbronchial Mediastinal Cryobiopsy for Adequacy of Next Generation Sequencing

Recruiting
PHASE4Ages 18+InterventionalDiagnostic
Vanderbilt-Ingram Cancer Center
~250 participants
Updated 2026-02-02 on ClinicalTrials.gov
What's tested:Endobronchial ultrasound with transbronchial needle aspirationBronchoscopyCryobiopsy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of samples sufficient for next-generation sequencing testing
Measured over Up to 12 months
Lung Cancer
1 sites across 1 states
Tennessee1
  • Fabien Maldonado, MD · PRINCIPAL_INVESTIGATOR · Vanderbilt University/Ingram Cancer Center
Vanderbilt-Ingram Services for Timely Access
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Lesions on PET or CT concerning for primary or metastatic malignancy that are amenable to biopsy by linear EBUS
Malignant cells present on rapid on-site cytological evaluation (ROSE)

Exclusion

Patient is known to be less than 18 years old
Patient is known to be pregnant
Patient is known to be a prisoner
Operator deems lesion is not safe to biopsy
  • Proportion of samples sufficient for next-generation sequencing testingUp to 12 months

    Comparison of samples between arms that meet sufficiency criteria for NGS