Mindfulness for Chronic Low Back Pain Study

This study is looking into how mindfulness meditation can help people with chronic low back pain (pain lasting at least 3 months). It uses a special approach called Mindfulness-Based Stress Reduction, which involves turning everyday activities like breathing and walking into meditation to increase awareness. Researchers want to understand how your mind and body react to pain and how mindfulness can help. They will use artificial intelligence to find unique patterns in people's biology, psychology, and social lives that predict how well they respond to mindfulness. The main goal is to see if mindfulness can improve your pain, enjoyment of life, and general activity levels over 6 months. You can join if you have chronic low back pain, are 18 or older, and speak English. The study is currently unclear on its recruitment status.

Study design
This interventional study plans to enroll 350 participants. It will use machine learning to identify markers that predict response to Mindfulness-Based Stress Reduction.
What's involved
You will participate in an 8-week Mindfulness-Based Stress Reduction program, meeting weekly via Zoom for 90 minutes. Data will be collected at baseline, 4 weeks, program completion, 4 months, and 6 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months after starting the study to determine the durability of effects.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06106191

Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment

Recruiting
NAAges 18+InterventionalTreatment
Boston Medical Center
~350 participants
Updated 2026-06-30 on ClinicalTrials.gov
What's tested:Mindfulness meditationPerspectives on painDiscussion

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pain, Enjoyment, General activity (PEG) composite score
Measured over 6 months
Chronic Low-back Pain
1 sites across 1 states
Massachusetts1
  • Natalia Morone, MD MS · PRINCIPAL_INVESTIGATOR · Boston Medical Center
  • Jean King, PhD · PRINCIPAL_INVESTIGATOR · Worcester Polytechnic Institute
  • Emmanuel Agu, PhD · PRINCIPAL_INVESTIGATOR · Worcester Polytechnic Institute

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Chronic low back pain, which is pain that persists for at least 3-months and has resulted in pain on at least half the days in the past 6 months
Willing and able to provide online or telephone informed consent
Speak English as the intervention manual is currently written in English

Exclusion

Red flags- recent (past month) worsening of pain, unexplained fever, unexplained weight loss
Pregnancy
Metastatic cancer
Not a patient at a participating clinic or persons not planning to continue as a patient at a participating clinic for 6 or more months
  • Pain, Enjoyment, General activity (PEG) composite score6 months

    The PEG is a 3-question scale: "pain average", "interference with general activity" and "interference with enjoyment of life". Each question is on a 0-10 scale, and total PEG is the average. Scores can range from 0-30 and \<12=Mild,12 to \<21 = Moderate, 21 to 30 = Severe chronic pain.