Iberdomide and Daratumumab for Multiple Myeloma After Transplant

This study is looking at whether a combination of two drugs, Iberdomide and Daratumumab, can help patients with multiple myeloma after they've had an autologous stem cell transplant (ASCT). The goal is to see if this treatment can effectively reduce or eliminate any remaining cancer cells (minimal residual disease, or MRD) and if it's a safe option. You might be able to join if you have multiple myeloma, have already received Daratumumab as part of your initial treatment, and have had an ASCT 90-150 days ago without your disease getting worse. The study aims to enroll 60 participants. The main way they'll measure success is by checking if your MRD is gone after 12 months.

Study design
This is an interventional study with a planned enrollment of 60 participants. It is a Phase 2 trial, meaning it's designed to assess the effectiveness and safety of the treatment.
What's involved
You would provide informed consent and complete screening assessments within 28 days before starting treatment. These assessments include specific laboratory tests and a medical evaluation.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 12 months, which suggests participants will be followed for at least that long to assess the rate of MRD negativity.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06107738

Iberdomide and Daratumumab as Maintenance Therapy After an Autologous Stem Cell Transplant for Multiple Myeloma

Recruiting
PHASE2Ages 18+InterventionalTreatment
Barbara Ann Karmanos Cancer Institute
~60 participants
Updated 2026-06-26 on ClinicalTrials.gov
What's tested:IberdomideDaratumumab/rHuPH20 Co-formulation

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rate of MRD (-) at 12 months
Measured over 12 months
Multiple Myeloma
2 sites across 1 states
Michigan2
  • Jeffrey Zonder, M.D. · PRINCIPAL_INVESTIGATOR · Barbara Ann Karmanos Cancer Institute

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  • Rate of MRD (-) at 12 months12 months

    Summarized by a binomial response rate and its associated 2-sided 90% confidence interval (CI) using Pearson-Klopper method.