Losartan for Preventing Arthrofibrosis After Total Knee Replacement
This study is investigating whether Losartan, a medication, can help reduce or prevent arthrofibrosis (stiffness and scarring around a joint) after total knee replacement surgery. Researchers want to see if taking Losartan for 28 days after your surgery improves your knee's movement and reduces thickening of the joint capsule. You could be eligible if you are at least 18 years old, planning to have a total knee replacement on one knee, and can give your own consent. The study aims to enroll 120 participants and is currently recruiting.
- Study design
- This is a double-blind, randomized, placebo-controlled study, meaning neither you nor your doctors will know if you are receiving Losartan or an inactive placebo. Approximately 120 participants will be enrolled.
- What's involved
- You would take an oral tablet (Losartan or placebo) for 28 days after your knee replacement surgery. Your knee's range of motion and joint capsule thickness will be measured at the start, 6 weeks, and 3 months after surgery.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your progress will be followed for up to 3 months after your surgery.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan
At a glance
Conditions
NCT06108063
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
The Steadman Clinic
Vail, Coloradostudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Johnny Huard, PhD · PRINCIPAL_INVESTIGATOR · Steadman Philippon Research Institute
- Scott Tashman, PhD · PRINCIPAL_INVESTIGATOR · Steadman Philippon Research Institute
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Quantitative Ultrasound Measurement of Capsular Thickness at Lateral RetinaculumBaseline, 6 weeks post-op, and 3 months post-op
Thickness of knee joint capsule will be measured using quantitative ultrasound. The thickness will be measured using the distance between the two bright echoes seen on the ultrasound image that correspond to the superficial and deep edges of the capsule.
- Knee Range of MotionBaseline, 6 weeks post-op, and 3 months post-op
Reported as degree of knee Flexion/Extension