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Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

This pilot study is looking at a treatment called Micro Current Neurofeedback Device using Low-Frequency Pulse-Based Transcranial Electrical Stimulation (LIP-tES) for people who have photosensitivity (light sensitivity) after a mild traumatic brain injury (mTBI). The study aims to see if this neurofeedback device can reduce your light sensitivity symptoms. You might be able to join if you are 18-65 years old, have a documented history of mTBI at least 6 months ago, and experience photosensitivity. You also need to have had a recent eye exam showing good vision and healthy eyes. The main goal is to measure changes in your photosensitivity symptoms using a survey called the Utah Photophobia Symptom Impact Scale (UPSIS). The study plans to enroll 36 participants, but its current status is unclear.

Study design
This is an interventional pilot study planning to enroll 36 participants to test a neurofeedback device.
What's involved
Your photosensitivity symptoms will be measured at the start and then every two weeks through the end of treatment, which is an average of 6 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your photosensitivity symptoms will be measured every two weeks through the end of treatment, which is an average of 6 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06109909

Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury

Recruiting
NAAges 18–65InterventionalTreatment
VA Office of Research and Development
~36 participants
Updated 2025-12-16 on ClinicalTrials.gov
What's tested:Micro Current Neurofeedback Device using Low-Frequency Pulse-Based Transcranial Electrical Stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Utah Photophobia Symptom Impact Scale (UPSIS)
Measured over Baseline and again every two weeks through end of treatment, average of 6 weeks

Conditions

Mild Traumatic Brain Injury
Photophobia

Explore related trials

PhotophobiaTraumatic Encephalopathy

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • Francesca C Fortenbaugh, PhD · PRINCIPAL_INVESTIGATOR · VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Who to contact

Francesca C Fortenbaugh, PhD
[email protected]
(857) 364-4362
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Ages 18-65
Documented history of mTBI at least 6 months prior to initial study visit
Documented symptoms of photosensitivity
Eye exam within the last 12 months documenting best-corrected acuity of 20/20 or better, normal pupillary function, color vision, no abnormalities on OCT scan, and normal Humphrey Visual Field test

Exclusion

History of strabismus or amblyopia
Significant ocular media opacity that could reduce the amount of light entering the pupil in one or both eyes
Previous or current history of retinal or optic nerve pathology in one or both eyes
History of stroke and/or visual neglect
History of neurodegenerative disease (e.g., Parkinson's, multiple sclerosis)
History of epilepsy or seizures
History of motor tics
Current use of medications or substances that may severely affect pupillary response and/or increase photosensitivity
Individuals with impaired decision-making capacity
Illiterate or no English language proficiency

What this trial measures

  • Change in Utah Photophobia Symptom Impact Scale (UPSIS)Baseline and again every two weeks through end of treatment, average of 6 weeks

    The UPSIS questionnaire is a 17-item questionnaire designed to quantitatively assess photosensitivity symptoms and their impact on activities of daily living. Scores range from 0-80 with higher values indicating more severe photosensitivity symptoms.