The SUGAR Study: SBRT and Relugolix for Prostate Cancer

This study is looking at treatments for prostate cancer in men aged 18 and older. It's testing Stereotactic Body Radiotherapy (SBRT), a standard radiation treatment, either alone or combined with Relugolix (Orgovyx), an oral medication. Relugolix is taken once a day for 30 days. Participants will be randomly assigned to receive one of these treatments. The main goal is to see if combining SBRT with Relugolix leads to a better prostate-specific antigen (PSA) nadir (the lowest point your PSA reaches after treatment) compared to SBRT alone. We also want to see if this combination is better for sexual and hormonal function. The study plans to enroll 60 participants, but its current status is unclear.

Study design
This is an interventional study where participants will be randomly assigned to receive either SBRT alone or SBRT combined with Relugolix. It plans to enroll 60 participants.
What's involved
Participants will take Relugolix orally once daily for 30 days if assigned to that group, and will receive SBRT radiation treatment.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, PSA nadir, will be measured for up to 2 years after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06111781

The SUGAR Study; SBRT and Relugolix) for Prostate Cancer

Recruiting
PHASE2Ages 18+InterventionalTreatment
Yale University
~60 participants
Updated 2026-07-21 on ClinicalTrials.gov
What's tested:Relugolix 120 MG [Orgovyx]SBRT standard of care radiotherapy treatment

At a glance

Recruiting sites
3 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of participants that attain PSA nadir
Measured over up to 2 years post treatment
Prostate Cancer
4 sites across 4 states
Connecticut1
New Hampshire1
New York1
Washington1
  • James Yu · PRINCIPAL_INVESTIGATOR · Yale University

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  • Proportion of participants that attain PSA nadirup to 2 years post treatment

    The proportion of men who undergo SUGAR that attain PSA nadir of \<= 0.2ng/mL compared to SBRT alone.