MDMA-assisted Prolonged Exposure for PTSD in Veterans

This study is looking at how effective and safe a treatment combining MDMA (3,4 Methylenedioxymethamphetamine) with Prolonged Exposure (a type of therapy) is for veterans with Post-Traumatic Stress Disorder (PTSD). You might be able to join if you are a veteran between 18 and 64 years old, have PTSD, and can speak and read English. The study will measure changes in your PTSD symptoms as rated by a clinician, from the start of the study up to four months after treatment. The current status of this study is unclear, but it plans to enroll between 10 and 20 veterans.

Study design
This is a randomized pilot study, meaning participants will be assigned by chance to receive different doses of MDMA. It plans to enroll between 10 and 20 U.S. veterans.
What's involved
You would commit to medication dosing, therapy sessions, follow-up sessions, completing evaluation instruments, and necessary phone calls. This includes twelve 90-minute Prolonged Exposure sessions over approximately three weeks, with some sessions occurring daily or every other day.
Compensation
Not stated in the trial record.
Follow-up
Your PTSD symptoms will be measured up to four months after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06117306

MDMA-assisted Massed Prolonged Exposure for PTSD

Active, Not Recruiting
PHASE3Ages 18–64InterventionalTreatment
Healing Breakthrough
~20 participants
Updated 2026-08-26 on ClinicalTrials.gov
What's tested:3,4 MethylenedioxymethamphetamineProlonged Exposure

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clinician-rated PTSD symptoms
Measured over Baseline - 4-months post-treatment
Post-Traumatic Stress Disorder
1 sites across 1 states
California1
  • Leslie Morland, Psy.D. · PRINCIPAL_INVESTIGATOR · San Diego Veterans Affairs Health System

This trial hasn't published a contact. View it on ClinicalTrials.gov

  • Clinician-rated PTSD symptomsBaseline - 4-months post-treatment

    The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) is a 20-item diagnostic interview administered by trained evaluators to assess PTSD in a participant. Based on DSM-5 diagnostic criteria, evaluators ask about the severity of four PTSD-related symptom clusters: re-experiencing, avoidance, negative alterations in cognition and mood, and alterations in arousal and reactivity. The evaluator rates responses on a 5-point Likert scale (0 = Absent to 4 = Extreme/Incapacitating). Total scores range from 0 to 80 with higher scores indicating greater severity.