MDMA-assisted Prolonged Exposure for PTSD in Veterans
This study is looking at how effective and safe a treatment combining MDMA (3,4 Methylenedioxymethamphetamine) with Prolonged Exposure (a type of therapy) is for veterans with Post-Traumatic Stress Disorder (PTSD). You might be able to join if you are a veteran between 18 and 64 years old, have PTSD, and can speak and read English. The study will measure changes in your PTSD symptoms as rated by a clinician, from the start of the study up to four months after treatment. The current status of this study is unclear, but it plans to enroll between 10 and 20 veterans.
- Study design
- This is a randomized pilot study, meaning participants will be assigned by chance to receive different doses of MDMA. It plans to enroll between 10 and 20 U.S. veterans.
- What's involved
- You would commit to medication dosing, therapy sessions, follow-up sessions, completing evaluation instruments, and necessary phone calls. This includes twelve 90-minute Prolonged Exposure sessions over approximately three weeks, with some sessions occurring daily or every other day.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your PTSD symptoms will be measured up to four months after treatment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
MDMA-assisted Massed Prolonged Exposure for PTSD
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Leslie Morland, Psy.D. · PRINCIPAL_INVESTIGATOR · San Diego Veterans Affairs Health System
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
What this trial measures
- Clinician-rated PTSD symptomsBaseline - 4-months post-treatment
The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) is a 20-item diagnostic interview administered by trained evaluators to assess PTSD in a participant. Based on DSM-5 diagnostic criteria, evaluators ask about the severity of four PTSD-related symptom clusters: re-experiencing, avoidance, negative alterations in cognition and mood, and alterations in arousal and reactivity. The evaluator rates responses on a 5-point Likert scale (0 = Absent to 4 = Extreme/Incapacitating). Total scores range from 0 to 80 with higher scores indicating greater severity.