Observational Study of Brain-Gut Axis and Gut Microbiome in Brain Lesions

This study is looking at how the tiny living organisms in your gut (your gut microbiome) might affect brain tumors. Researchers want to understand if there's a connection between your gut health and how brain tumors develop, grow, and respond to treatments like chemotherapy, radiation, or immunotherapy. You could join if you are 18 or older and are having surgery for a central nervous system tumor. The main goal is to collect samples and information to build a resource (biorepository) that will help future research. This collection is expected to take about one year, or until enough samples are gathered based on treatment schedules. The study is currently observational, meaning it involves collecting information and samples without giving any new treatments.

Study design
This is an observational study planning to enroll 100 participants. It is not testing a specific drug or intervention.
What's involved
You would provide blood, tissue, saliva, urine, and stool samples, and complete questionnaires.
Compensation
Not stated in the trial record.
Follow-up
The primary goal of establishing the biorepository is measured at approximately 1 year, or until samples have been collected based on scheduled treatment.

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NCT06117930

Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research

Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~100 participants
Updated 2026-02-05 on ClinicalTrials.gov
What's tested:Non-Interventional Study

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Establish the Mayo Clinic Florida Tumor-Gut Axis Biorepository
Measured over Approximately 1 year, or until samples have been collected based on scheduled treatment.
Malignant Central Nervous System Neoplasm
1 sites across 1 states
Florida1
  • Alfredo Quinones-Hinojosa, M.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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Eligibility criteria

Inclusion

All patients undergoing resection for a tumor of the central nervous system and associated controls are eligible to participate in this study.

Exclusion

Excluded samples will be from patients younger than 18 years old. There are no exclusions due to race/sex.
  • Establish the Mayo Clinic Florida Tumor-Gut Axis BiorepositoryApproximately 1 year, or until samples have been collected based on scheduled treatment.

    Biological samples such as stool, urine, blood, saliva, and/or tissue will be collected for storage in the Tumor-Gut Axis Biorepository. Samples may be collected at any of the following time periods during study participation: before/after steroid therapy, before/after surgical intervention, before/after radiation therapy, and before/after chemotherapy.