Adaptive Treatment for Early Smoking Cessation Relapse

This study is looking for smokers who want to quit and have found it difficult to stop using medications. It aims to improve how treatment decisions are made for these individuals. You'll receive free products for 12 weeks, which could include nicotine replacement therapies (patches and lozenges), varenicline (a medication to help you quit smoking), or e-cigarettes (a harm reduction product). The specific treatment you receive will depend on how you respond to earlier treatments. The study will measure if you are still smoking after your initial medication course at 8 weeks. This study is currently unclear about its recruitment status, but plans to enroll 544 participants.

Study design
This interventional study plans to enroll 544 participants. It will test different approaches to help people quit smoking.
What's involved
All visits and assessments will be remote. You will complete 8 surveys over six months.
Compensation
All treatments will be provided free of charge for the first 12 weeks.
Follow-up
The study team will contact participants 6 months after the first study phone call to complete another survey.

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NCT06118502

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

Recruiting
NAAges 21+InterventionalTreatment
Medical University of South Carolina
~544 participants
Updated 2026-08-12 on ClinicalTrials.gov
What's tested:Switching to a different medicationContinued use of the same medicationSwitching to a harm reduction tobacco product

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Non-responders after initial course of FDA-approved medication
Measured over 8 weeks
Cigarette Smoking
Smoking Behaviors
Treatment
1 sites across 1 states
South Carolina1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Smokers who want to quit

Exclusion

Non-smokers
  • Non-responders after initial course of FDA-approved medication8 weeks

    7-day point prevalence abstinence at Week 8 among non-responders at Week 4