This study is looking at two different surgical approaches for high-grade glioma (a type of brain tumor) to see which one works best. These approaches are called Supramaximal Resection and Maximal Safe Resection. Researchers want to understand if removing more of the tumor, including parts that don't show up as clearly on scans (Supramaximal Resection), leads to better survival and fewer problems after surgery compared to removing as much as the surgeon thinks is safe (Maximal Safe Resection). They will also look at how these surgeries affect your brain function, thinking, and overall quality of life. This study is for adults aged 18 to 90 who have been diagnosed with high-grade glioma. The study aims to enroll 784 participants, but its current status is unclear.

Study design

This is an international, observational study with two groups of participants (2-arm cohort study). It aims to include 784 participants, who will be assigned to either the supramaximal or maximal safe resection group.

What's involved

You would have evaluations at the start of the study, and then at 6 weeks, 3 months, and 6 months after surgery. These evaluations include tests for motor, language, and cognitive functions.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for overall survival for up to 5 years after surgery, and neurological problems will be checked at 6 weeks postoperatively.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.