Telavancin in Patients with External Ventricular Drainage

This study is looking at how well the antibiotic telavancin gets into the brain and spinal fluid (cerebrospinal fluid or CSF) of critically ill patients. These patients have had a type of bleeding in the brain called a subarachnoid hemorrhage (SAH) and have a special drain (external ventricular drainage or EVD) to help manage fluid around the brain. Researchers want to see if telavancin reaches high enough levels in the CSF to fight infections. You might be able to join if you are an adult between 18 and 85 years old, have an EVD, and meet other health requirements. The study aims to enroll 20 participants and will measure telavancin levels over 3 days.

Study design
This is a prospective cohort study, meaning researchers will follow a group of patients over time. It aims to include 20 participants.
What's involved
You would receive telavancin intravenously (through a vein) once a day for 3 days. Blood and CSF samples will be taken during this time.
Compensation
Not stated in the trial record.
Follow-up
Telavancin levels will be measured for 3 days.

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NCT06119061

Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage

Recruiting
PHASE4Ages 18–85InterventionalTreatment
Aaron Cook
~20 participants
Updated 2025-12-26 on ClinicalTrials.gov
What's tested:Telavancin Injection

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Determine the CNS penetration of telavancin in critically ill patients with External Ventricular Drainage
Measured over 3 days
Subarachnoid Hemorrhage, Aneurysmal
1 sites across 1 states
Kentucky1
  • Aaron M Cook, PharmD · PRINCIPAL_INVESTIGATOR · University of Kentucky

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Eligibility criteria

Inclusion

Adult aged 18-85 years
Actively draining ventriculostomy

Exclusion

history of hypersensitivity to telavancin or similar agents
reduced renal function (estimated creatinine clearance \< 50/ml) at the time of consent
severe anemia (hemoglobin \< 7gm/dl)
vulnerable population (pregnant, prisoner)
concomitant antimicrobial therapy
  • Determine the CNS penetration of telavancin in critically ill patients with External Ventricular Drainage3 days

    Telavancin concentrations in CSF drawn from external ventricular drains will be compared to samples from the serum to determine the degree to which telavancin is present in the CNS