Telavancin in Patients with External Ventricular Drainage
This study is looking at how well the antibiotic telavancin gets into the brain and spinal fluid (cerebrospinal fluid or CSF) of critically ill patients. These patients have had a type of bleeding in the brain called a subarachnoid hemorrhage (SAH) and have a special drain (external ventricular drainage or EVD) to help manage fluid around the brain. Researchers want to see if telavancin reaches high enough levels in the CSF to fight infections. You might be able to join if you are an adult between 18 and 85 years old, have an EVD, and meet other health requirements. The study aims to enroll 20 participants and will measure telavancin levels over 3 days.
- Study design
- This is a prospective cohort study, meaning researchers will follow a group of patients over time. It aims to include 20 participants.
- What's involved
- You would receive telavancin intravenously (through a vein) once a day for 3 days. Blood and CSF samples will be taken during this time.
- Compensation
- Not stated in the trial record.
- Follow-up
- Telavancin levels will be measured for 3 days.
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Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Aaron M Cook, PharmD · PRINCIPAL_INVESTIGATOR · University of Kentucky
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Determine the CNS penetration of telavancin in critically ill patients with External Ventricular Drainage3 days
Telavancin concentrations in CSF drawn from external ventricular drains will be compared to samples from the serum to determine the degree to which telavancin is present in the CNS