Pulse-Width Modulation Study for Spinal Fusion and Stenosis
This study is looking at a new way to check the placement of screws during spinal fusion surgery. Researchers will use "pulse-width modulation" (a way to change electrical signals) to stimulate the pedicle screws (screws placed in the spine) with three different settings: 0.4 milliseconds, 0.2 milliseconds, and 0.05 milliseconds. The goal is to see how these different settings affect the body's response, specifically the CMAP (Compound Muscle Action Potential, a measure of nerve activity). You might be able to join if you are 18 or older, having surgery that involves pedicle screw placement, and will have your nerves monitored during the operation. This study is currently unclear on its recruitment status and plans to enroll 50 participants.
- Study design
- This is an interventional study, meaning participants will receive a specific intervention. It plans to include 50 participants.
- What's involved
- You would have the pedicle screws stimulated with different pulse-width settings during your surgery, after the screws are placed.
- Compensation
- Not stated in the trial record.
- Follow-up
- The main measurement (CMAP response) is taken within the operating room, on the day of surgery.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Pulse-Width Modulation
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Linton Evans, Dr. · PRINCIPAL_INVESTIGATOR · Dartmouth-Hitchcock Medical Center
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- CMAP response under three different pulse-width settingsWithin operating room upon completion of pedicle screw placement. 1 day
Upon completion of the pedicle screw placements, each screw will be stimulated utilizing three different pulse-width settings, 0.4 milliseconds, 0.2 milliseconds, and 0.05 milliseconds. The stimulation intensity required to elicit a compound muscle action potential (CMAP) will be recorded for each pulse-width parameter. This is measured in microvolts (uV).