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Cardiovascular Effects of a Healthy Diet with Eggs

This study is looking at how a healthy diet that includes different amounts of Whole Eggs affects your heart health. Researchers want to see if eating 2 eggs per day compared to 3 eggs per week, as part of a healthy diet, changes your LDL-cholesterol (often called "bad" cholesterol). You might be able to join if you are between 30 and 60 years old, have LDL-C between 115 and 190 mg/dL, a BMI between 25-35 kg/m2, and currently eat less than 14 eggs per week. The study aims to enroll 65 people, but its current recruitment status is unclear.

Study design
This is a randomized, crossover study where participants will follow different healthy diets for 4 weeks each. It involves comparing a healthy diet with 2 eggs per day to a healthy diet with 3 eggs per week.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your LDL-cholesterol will be measured after 4 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06120400

Cardiovascular Effects of a Healthy Dietary Pattern Containing Eggs

Recruiting
PHASE3Ages 30–60InterventionalPrevention
Penn State University
~65 participants
Updated 2025-07-20 on ClinicalTrials.gov
What's tested:Whole Egg

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
LDL-cholesterol change
Measured over 4 weeks

Conditions

Cardiovascular Diseases

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Cardiovascular Disorder

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Kristina Petersen · PRINCIPAL_INVESTIGATOR · The Pennsylvania State University

Who to contact

Kristina Petersen, PhD
[email protected]
814-865-7206
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

LDL-C ≥115 mg/dL and ≤190 mg/L
BMI of 25-35 kg/m2
Intake of \<14 eggs/week for the prior 3 months
Blood pressure \<140/90 mmHg
Fasting blood glucose \<126 mg/dL
Fasting triglycerides \<350 mg/dL
≤10% change in body weight in the prior 6 months

Exclusion

Type 1 or type 2 diabetes or fasting blood glucose ≥126 mg/dL
Prescription of anti-hypertensive, lipid lowering or glucose lowering drugs
Intake of supplements that affect the outcomes of interest and unwilling to cease during the study period
Diagnosed liver, kidney, or autoimmune disease
Prior cardiovascular event (e.g., stroke, heart attack)
Current pregnancy or intention of pregnancy within the next 6 months
Lactation within prior 6 months
Follows a vegetarian or vegan diet
Food allergies/intolerance/sensitives/dislikes of foods included in the study menu
Antibiotic use within the prior 1 month
Oral steroid use within the prior 1 month
Use of tobacco or nicotine containing products with in the past 6 months
Cancer any site within the past 10 years (eligible if ≥10 years without recurrence) or non-melanoma skin cancer with in the past 5 years (eligible if ≥5 years without recurrence)
Participation in another clinical trial within 30 days of baseline
Currently following a restricted or weight loss diet
Prior bariatric surgery
Intake of \>14 alcoholic drinks/week and/or lack of willingness to consume a maximum of two standard drinks per week while enrolled in the study and/or not willing to avoid alcohol consumption for 48 hour prior to test visits

What this trial measures

  • LDL-cholesterol change4 weeks

    Assessed from fasting blood draw expressed in mg/dL. LDL-cholesterol will be measured directly via enzymatic assay. Change in LDL-cholesterol will be calculated as the mean of the end of diet measures (i.e., mean of day 1 and day 2 values) minus the mean of the baseline measures (i.e., mean of day 1 and day 2 values).