Freenome Multiomics Blood Test for Lung Cancer Screening

This study, called PROACT LUNG, is looking for 20,000 people to help test a new blood test called the Freenome Multiomics Blood Test. This test aims to find lung cancer early. You can join if you are 50 or older, have a history of smoking (at least 20 pack-years, which is like smoking a pack a day for 20 years), and are able to understand and sign consent forms. The study will check how well the Freenome Multiomics Blood Test can find lung cancer (its sensitivity) and how well it can correctly identify people without lung cancer (its specificity) over 12 months. This is an observational study, meaning researchers will watch and collect information without giving you a specific treatment.

Study design
This is an observational study involving 20,000 participants. It is designed to evaluate the performance of the Freenome Multiomics Blood Test.
What's involved
You will have 50 ml of blood collected and undergo a standard-of-care screening Low-Dose Computed Tomography (LDCT) scan. You will also provide demographic and clinical data.
Compensation
Not stated in the trial record.
Follow-up
The study measures sensitivity and specificity in detecting lung cancer at 12 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06122077

Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

Recruiting
Not specifiedAges 50+Observational
Freenome Holdings Inc.
~20,000 participants
Updated 2025-08-05 on ClinicalTrials.gov
What's tested:blood draw

At a glance

Recruiting sites
36 of 36 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sensitivity and specificity in detecting lung cancer
Measured over 12-Months
Lung Cancer Diagnosis
36 sites across 22 states
Florida6
Pennsylvania5
Illinois3
Kansas2
South Carolina2
Texas2
California1
Connecticut1
  • Victoria Sumner · STUDY_DIRECTOR · Freenome Holdings Inc.

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  • Sensitivity and specificity in detecting lung cancer12-Months

    Clinical performance of the Freenome Blood Test, including sensitivity and specificity, in detecting lung cancer in subjects with positive and negative lung cancer outcomes during a 12-month follow-up period