This observational study wants to understand how androgens (male hormones that women also have) might affect nonalcoholic fatty liver disease (NAFLD) in young women. NAFLD is when fat builds up in the liver, which can lead to damage like inflammation or scarring. Researchers are especially interested in young women with polycystic ovary syndrome (PCOS), as they often have high androgen levels and a higher risk of NAFLD. The study will follow women with and without PCOS to see how their liver stiffness changes over three years and how fat around their organs (visceral adipose tissue or VAT) is linked to the severity of a more advanced liver disease called MASH (metabolic associated steatohepatitis, formerly NASH). This study is for women aged 18 to 42 who have MASH and/or PCOS, or neither. You cannot join if you drink a lot of alcohol, are pregnant, have other causes of liver fat, or have had recent significant weight loss. The study aims to enroll 150 participants, but its current status is unclear.

Study design

This is an observational study, meaning researchers will watch and collect information over time without giving any specific treatments. It aims to include 150 women.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for three years to measure changes in liver stiffness.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.