REACTplusNMES Trial for Stroke Recovery
This study is looking at ways to improve balance and prevent falls in people who have had a stroke. It compares two types of training: "Reactive balance training with Neuromuscular Electrical Stimulation (REACT-NMES)" and "Reactive balance training without Neuromuscular Electrical Stimulation (REACT)". Both groups will use a special treadmill that creates slips to help improve balance. The REACT-NMES group will also receive electrical stimulation to their leg muscles. You might be able to join if you are 18-90 years old, had a stroke more than 6 months ago, can walk for at least 2 minutes, and can understand English. The study will measure changes in falls and how well you can react to balance challenges. The current status of this study is unclear.
- Study design
- This is a double-blinded, randomized controlled trial that plans to enroll 46 participants. Participants will be randomly assigned to one of two groups.
- What's involved
- Participants will undergo 12 training sessions over 6 weeks, with 24 slips per session. Measurements will be taken at the beginning of the study and again after 9 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed up to 9 weeks after the start of the study for primary endpoint measurements.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The REACTplusNMES Trial: A Double-blinded RCT
At a glance
Conditions
NCT06127602
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Illinois at Chicago
Chicago, Illinoisstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Tanvi Bhatt · PRINCIPAL_INVESTIGATOR · University of Illinois at Chicago
Who to contact
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Inclusion
Exclusion
What this trial measures
- Change in FallsPre-training (during week 2 i.e., Session 2), Post-training (during week 9 i.e., Session 16)
A fall will be detected when the force exerted through the safety-harness load cell exceeds 30% of a person's body weight and verified with video analysis. Otherwise, the trial will be a balance recovery. Higher percentages indicate more falls.
- Change in Reactive StabilityPre-training (during week 2 i.e., Session 2), Post-training (during week 9 i.e., Session 16)
Reactive stability (dimensionless) will be measured at the time point of compensatory limb touchdown after slipping. Stability will be calculated as the shortest distance from the COM state to the backward balance loss threshold. The instantaneous COM state is determined by its position and velocity (computed from filtered marker data) relative to the BOS, normalized respectively to foot length and the square root of the product of gravitational acceleration and body height. Higher values indicate better reactive stability.
- Change in Proactive StabilityPre-training (during week 2 i.e., Session 2), Post-training (during week 9 i.e., Session 16)
Proactive stability (dimensionless) will be measured at the time point of slipping limb touchdown i.e., before slipping. Stability will be calculated as the shortest distance from the COM state to the backward balance loss threshold. The instantaneous COM state is determined by its position and velocity (computed from filtered marker data) relative to the BOS, normalized respectively to foot length and the square root of the product of gravitational acceleration and body height. Higher values indicate better proactive stability.
- Change in Vertical Limb supportPre-training (during week 2 i.e., Session 2), Post-training (during week 9 i.e., Session 16)
Vertical limb support (dimensionless) is quantified by the quotient of hip vertical velocity to its height (VZhip/ Zhip). Zhip will be obtained as the vertical distance of the bilateral hip midpoint to the surface of the platform and its vertical velocity (VZhip), as the first-order differentiation of hip height. Its positive direction is upward. Higher values indicate better vertical limb support.
- Change in Muscle synergiesPre-training (during week 2 i.e., Session 2), Post-training (during week 9 i.e., Session 16)
To assess the muscular synergies, electromyography sensors will be applied to four muscle groups on both lower limbs. The muscle groups include tibialis anterior, gastrocnemius, quadriceps and hamstring group of muscles. Higher values indicate more muscle synergies.
- Change in Perturbation-evoked potentialsPre-training (during week 2 i.e., Session 2), Post-training (during week 9 i.e., Session 16)
Data from different midline electroencephalographic (EEG) channels overlying lower limb frontal, sensorimotor and parietal regions will be used to extract the perturbation-evoked potentials (P1, N1, P2 and N2) to assess their spatio-temporal parameter (amplitude: microvolts, latency: seconds)
- Change in time-frequency powerPre-training (during week 2 i.e., Session 2), Post-training (during week 9 i.e., Session 16)
Data from different midline electroencephalographic channels overlying lower limb frontal, sensorimotor, and parietal regions will be used to extract the alpha, beta, theta, and gamma power (decibels). Higher values indicate more frequency power.