Mavoglurant for Alcohol Craving and Drinking in Heavy Drinkers
This study is looking at how a drug called mavoglurant affects alcohol craving and drinking in people who drink heavily and have Alcohol Use Disorder (AUD). You might be able to join if you are between 21 and 50 years old, can read English, and have been diagnosed with moderate or severe AUD. The researchers want to see if mavoglurant can reduce the number of drinks you consume and lessen your craving for alcohol over a short period. The study is currently unclear on its recruitment status.
- Study design
- This is a double-blind, placebo-controlled study with 63 participants. This means neither you nor the study team will know if you are receiving mavoglurant or a placebo (an inactive pill).
- What's involved
- You would attend two lab sessions, which include a Cue Exposure Paradigm (to measure craving) and an Alcohol Drinking Paradigm. There will also be follow-up appointments one week and one month after the sessions.
- Compensation
- Not stated in the trial record.
- Follow-up
- You will have follow-up appointments one week and one month after your lab sessions.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
At a glance
Conditions
Where it's being run
2 sites across 1 statesStudy leadership
- Suchitra Krishnan, PhD · PRINCIPAL_INVESTIGATOR · Yale University
Who to contact
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What this trial measures
- Change in the number of drinks consumedLab Session 1 (Day 1); Lab Session 2 (5-8 days after Lab Session 1).
The number of drinks consumed during the adlib session will be recorded
- Change in craving for alcoholLab Session 1 (Day 1); Lab Session 2 (5-8 days after Lab Session 1).
The Cue Exposure Paradigm (CEP) is used to measure craving for alcohol. The task uses a questionnaire that is in the form of a Visual Analog Scale (VAS). The endpoints will be marked with a 0 on the left indicating no craving and a 20 on the right indicating severe craving. Participants will indicate how strong they are craving to drink alcohol. The VAS takes 2-3 minutes to complete.