This study is looking at whether using cryotherapy (cold therapy) wraps combined with compression therapy (cryocompression) is as effective as cryotherapy wraps alone in preventing or reducing chemotherapy-induced peripheral neuropathy (nerve damage that can cause numbness, tingling, or pain) in women with gynecologic cancer. You could be eligible if you have ovarian, cervical, or endometrial cancer and are planning to receive at least six cycles of paclitaxel chemotherapy at Duke Cancer Center, Macon Pond, or Carilion Clinic in Roanoke, VA. The study aims to see if cryocompression is not worse than cryotherapy alone in improving your symptoms, as measured by a patient-reported survey called FACT-NTX. The study plans to include 190 participants.

Study design

This interventional study will randomly assign participants to receive either cryotherapy wraps plus compression therapy or cryotherapy wraps alone on their hands and feet. The study aims to enroll 190 participants.

What's involved

You would receive cryotherapy (+/- compression) during your taxane infusions. You would complete surveys about your symptoms, acceptability, and tolerability at each infusion visit.

Compensation

Not stated in the trial record.

Follow-up

Your symptoms will be assessed up to two months after completing chemotherapy, which is an average of 6 months from the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.