Ketamine's Effect on Spinal Cord Monitoring During Surgery
This study is looking at how the drug ketamine affects special measurements called motor evoked potentials (MEPs) during spine surgery. MEPs help doctors monitor your spinal cord's health during an operation. If you are an adult (over 18) having a posterior spinal fusion surgery, you might be able to join. You cannot join if you are allergic to ketamine, have certain heart conditions, uncontrolled high blood pressure, or a history of schizophrenia. During the surgery, you will receive increasing doses of ketamine, and doctors will measure your MEPs to see how they change. The main goal is to understand how ketamine impacts these measurements within 30 minutes of administration. The study plans to include 20 participants, but its current status is unclear.
- Study design
- This is an interventional study, meaning participants will receive a specific treatment (ketamine). It plans to enroll 20 adult patients.
- What's involved
- Participants will receive ketamine during their spinal fusion surgery, with MEPs measured at increasing doses.
- Compensation
- Not stated in the trial record.
- Follow-up
- MEPs will be measured at 30 minutes after ketamine administration.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effect of Ketamine on Intraoperative Motor Evoked Potentials
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Marc Buren, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in threshold motor evoked potentials (MEP) in response to intraoperative ketamine administration30 minutes
MEP helps to monitor the integrity and function of the spinal cord and alert the surgeon of any potential injury during the spine surgery. MEP amplitude will be measured at each of 3 ketamine doses and compared to baseline. The measurements will be at each dose change of ketamine approximately 10, 20 and 30 minutes after the start of the ketamine infusions.
- Change in supramaximal motor evoked potentials (MEP) in response to intraoperative ketamine administration30 minutes
MEP helps to monitor the integrity and function of the spinal cord and alert the surgeon of any potential injury during the spine surgery. MEP amplitude will be measured at each of 3 ketamine doses and compared to baseline. The measurements will be at each dose change of ketamine approximately 10, 20 and 30 minutes after the start of the ketamine infusions.
- Change in motor evoked potentials (MEP) facilitation in response to intraoperative ketamine administration30 minutes
MEP helps to monitor the integrity and function of the spinal cord and alert the surgeon of any potential injury during the spine surgery. MEP amplitude will be measured at each of 3 ketamine doses and compared to baseline. The measurements will be at each dose change of ketamine approximately 10, 20 and 30 minutes after the start of the ketamine infusions.