GETSET: Genetic Testing in Elective Single Embryo Transfer

This study, called GETSET, is looking at how preimplantation genetic testing for aneuploidy (PGT-A) affects pregnancy rates in women undergoing in vitro fertilization (IVF). PGT-A is a test that screens embryos for an abnormal number of chromosomes before they are transferred. You may be able to join if you are a woman between 35 and 40 years old, undergoing IVF with your own eggs, and using either ejaculated or testicular sperm. The main goal is to see if PGT-A leads to a higher ongoing pregnancy rate, which will be measured for up to two years. The current recruitment status is unclear.

Study design
This is a randomized controlled trial, meaning participants will be assigned by chance to one of two groups. About 240 women will participate in this study.
What's involved
You would undergo standard IVF procedures including ovarian hyper-stimulation, egg retrieval, fertilization, and embryo culture. Depending on your assigned group, your embryos may undergo PGT-A testing before a single embryo transfer.
Compensation
Not stated in the trial record.
Follow-up
Your ongoing pregnancy rate will be measured for up to two years after the embryo transfer.

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NCT06141135

GEnetic Testing in Elective Single Embryo Transfer (GETSET): A Randomized Clinical Trial

Recruiting
NAAges 35–40InterventionalTreatment
Genomic Prediction Inc.
~240 participants
Updated 2025-08-26 on ClinicalTrials.gov
What's tested:Preimplantation genetic testing for aneuploidy (PGTA)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ongoing Pregnancy Rate
Measured over Up to 2 years
Infertility, Female
1 sites across 1 states
Massachusetts1
  • Nathan Treff, PhD · PRINCIPAL_INVESTIGATOR · Genomic Prediction Clinical Labortory

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Eligibility criteria

Inclusion

Women undergoing IVF of between 35 and 40 years of age at IVF cycle start
Utilization of Intracytoplasmic Sperm Injection ICSI (recommended) or ---Traditional IVF
Utilization of ejaculated or testicular sperm
Utilization of autologous or donor sperm
All Controlled Ovarian Hyperstimulation (COH) protocols

Exclusion

Utilization of donor oocytes
Utilization of gestational carrier
Recurrent Pregnancy Loss (RPL) defined as ≥ 3 consecutive miscarriages
Recurrent Implantation Failure (RIF) defined as ≥ 3 more failed embryo transfers
Preimplantation genetic testing for monogenic/single gene disorders (PGT-M)
Translocation carriers
  • Ongoing Pregnancy RateUp to 2 years

    The number of participants who experience an ongoing clinical pregnancy rate after the 1st embryo transfer.