The PROMISE Study is an observational research study looking into how experiences during pregnancy, like infections, diet, and growth, might affect a child's risk of developing type 1 diabetes (T1D) and islet autoimmunity (when the body's immune system mistakenly attacks its own cells) later in life. We're also interested in why a child's risk of autoimmunity is higher when their father or a sibling has T1D, compared to when their mother has it. We are enrolling pregnant women where the baby's mother, father, or a full sibling has type 1 diabetes. The study will follow the children up to six years of age to see if they develop islet autoimmunity. This study does not involve any specific interventions or medications.

Study design

This is an observational study aiming to enroll 6000 participants. It is being conducted at multiple centers, including the Barbara Davis Center for Diabetes, Mt Sinai Hospital, Joslin Diabetes Center, and Ohio State University.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Children will be followed up to six years of age to measure islet autoimmunity.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.